2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.01D.03 Analysis of Lung Cancer Risk in Never Smokers with a Family History of Lung Cancer: A Cohort Study

EP.01D.03 Analysis of Lung Cancer Risk in Never Smokers with a Family History of Lung Cancer: A Cohort Study

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The cohort study assesses the risk of lung cancer linked to family history among never-smokers. The study included 213,423 participants from the Kangbuk Samsung Cohort Study, of which 13,858 reported a family history of lung cancer (FHLC). The study found that never-smokers with FHLC have a significantly higher risk of developing lung cancer, with an observed incident of lung cancer in 31 participants with FHLC (0.22%) compared to 172 without FHLC (0.086%). This translates to an unadjusted hazard ratio of 1.80, indicating that never-smokers with FHLC are 80% more likely to develop lung cancer than those without a family history. <br /><br />The study highlights that lung cancer among never-smokers is a rising concern in East Asia due to non-smoking-related risk factors, including age, family history, second-hand smoke exposure, and environmental pollutants like asbestos and radon. The findings underscore the significant influence of genetic predispositions on lung cancer risk, independent of smoking status.<br /><br />Data for this prospective cohort study was gathered from Korean adults undergoing health screenings between 2011 and 2021. FHLC was assessed using questionnaires, and lung cancer cases were tracked through the Korea National Cancer Incidence Database.<br /><br />The researchers emphasize that the risk notably increases after age 55, suggesting that incorporating FHLC into lung cancer screening models could improve early detection and preventive strategies for high-risk populations. This approach could be particularly beneficial in enhancing the screening processes and reducing lung cancer mortality through more targeted and personalized health interventions.

Asset Subtitle

Yun-Gyoo Lee

Meta Tag

Speaker Yun-Gyoo Lee

Topic Risk Factors, Risk Reduction & Tobacco Control

Keywords

lung cancer

never-smokers

family history

cohort study

risk factors

genetic predispositions

East Asia

screening models

environmental pollutants

preventive strategies