2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.02A.01 Gender-Specific Onset Age Distribution Among Different Driver Mutations in Lung Cancer

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The study examines gender-specific onset age distributions related to different driver mutations in non-small cell lung cancer (NSCLC). It is a retrospective analysis conducted on data from 8,704 patients treated at the First Affiliated Hospital of Guangzhou Medical University between 2009 and 2018. Patients were categorized into groups based on specific gene mutations including EGFR, KRAS, ALK, MET, ERBB2, ROS1, BRAF, RET, NRAS, NTRK, and wild-type (WT).<br /><br />Key findings highlight that driver mutations influence the age of onset differently across genders. EGFR mutations show no increasing trend with age in males but increased with age in females. The EGFR 19del mutation is associated with an earlier onset in males compared to females. Conversely, EGFR L858R mutations show later onset in females. Specific mutations like ALK, ROS1, and ERBB2 are associated with earlier onset regardless of gender, while mutations in the RAS gene family (KRAS, NRAS, BRAF, MET) tend to exhibit delayed onset.<br /><br />In the cohort, a higher mutation frequency of EGFR was observed in females, while KRAS mutations were more prevalent in males. Other mutations such as BRAF, NRAS, MET, ROS1, and WT were significantly more frequent in males. The average age at diagnosis was higher in males (60.47 years) than in females (57.35 years).<br /><br />The study concludes that the distribution of driver gene mutations varies with age and gender, suggesting that these factors exert significant influences on lung cancer phenotypes. It emphasizes the need for future studies with larger sample sizes and prospective designs to validate and expand on these findings. No external funding or conflicts of interest are reported in this study. For further information, inquiries were directed to the corresponding author via provided contact details.

Asset Subtitle

Huiting Wang

Meta Tag

Speaker Huiting Wang

Topic Tumor Biology – Preclinical Biology

Keywords

non-small cell lung cancer

driver mutations

EGFR

gender differences

age of onset

retrospective analysis

gene mutations

mutation frequency

lung cancer phenotypes

First Affiliated Hospital of Guangzhou Medical University