false
Catalog
2024 World Conference on Lung Cancer (WCLC) - ePos ...
EP.02B.08 Interrogating Sexual Dimorphism in Lung ...
EP.02B.08 Interrogating Sexual Dimorphism in Lung Cell Biology and Tumourigenesis for Cancer Treatment and Prevention in Never & Smokers
Back to course
Pdf Summary
The study "Interrogating Sexual Dimorphisms in Lung Cell Biology and Tobacco-unassociated Tumourigenesis" by Rachel Joyce and colleagues investigates the sex-based biological differences in lung cell biology linked to tobacco-unassociated lung cancer, focusing on female patients who predominantly suffer from this disease type. Australia's first National Lung Cancer Screening Program, launching in 2025, prioritizes patients with a significant smoking history, potentially excluding individuals with tobacco-unassociated lung cancer, underscoring the need for novel prevention strategies. <br /><br />The research delves into how sex and sex hormones influence lung epithelial cells, their microenvironment, and the development of tobacco-unassociated tumors. It examines the transcriptomes of healthy lung cells from never-smoking males and females at various developmental stages to identify sexually dimorphic gene expressions. The project also evaluates the molecular signatures of invasive mucinous lung adenocarcinoma (IMA) development in non-smoking male and female patients, highlighting that IMAs often appear in non-smoking or ex-smoking females without tobacco-related mutational signatures.<br /><br />RNA sequencing analyses using datasets from healthy lung cell subsets and IMA tumors reveal biologically conserved sexual dimorphisms in lung cell transcriptomes, which appear to change with age. These changes suggest that hormonal differences could significantly influence lung cancer development pathways. Identifying unique sex-based molecular signatures associated with IMA development in both sexes points to potential avenues for tailored preventative therapies.<br /><br />This research highlights the necessity of understanding the sex-specific molecular basis of tobacco-unassociated lung cancer to design effective, targeted prevention strategies that can serve underrepresented groups, particularly women, within the broader lung cancer health programs.
Asset Subtitle
Rachel Joyce
Meta Tag
Speaker
Rachel Joyce
Topic
Tumor Biology – Preclinical Biology
Keywords
sexual dimorphisms
lung cell biology
tobacco-unassociated lung cancer
female patients
National Lung Cancer Screening Program
sex hormones
transcriptomes
invasive mucinous adenocarcinoma
RNA sequencing
molecular signatures
×
Please select your language
1
English