2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.02F.04 Development and Validation of an ADRB2-based Prognostic Model for Non-Small Cell Lung Cancer

Pdf Summary

The document outlines a study focused on developing and validating an ADRB2-based prognostic model for non-small cell lung cancer (NSCLC), which is a prevailing cause of cancer-related mortality globally. ADRB2 expression is notably elevated in NSCLC tumors compared to normal lung tissue. The study created a scoring system centered on ADRB2-related dysregulated genes, which are linked to immunological traits, thereby offering insights into the multi-omics framework of global regulatory networks.<br /><br />Researchers identified dysregulated ADRB2-associated genes in NSCLC through analysis of the TCGA database, investigating their biological processes and pathways. A clinical score model was developed, correlating these genes with immune checkpoints and cell infiltration. This endeavor also unveiled possible regulatory mechanisms and therapeutic targets using multi-omics data.<br /><br />Key findings indicate that increased ADRB2 expression is linked to poor prognosis in NSCLC, suggesting its potential as a biomarker. Dysregulated genes associated with ADRB2 were involved in important signaling pathways, such as the JAK-STAT signaling pathway and cytokine-cytokine receptor interactions, leading to reprogramming of NSCLC's immune microenvironment. The study also identified potential therapeutic targets like SLC6A14, implying that drugs like Valaciclovir and Valganciclovir might be effective treatment options for NSCLC.<br /><br />The ADRB2-based clinical score model is posited as a valuable tool for personalizing treatment regimens for specific patients, emphasizing the need for further research to affirm the biological significance and functions of the identified genes. This model holds significant prognostic power and could enhance diagnostic processes in NSCLC.

Asset Subtitle

Ting Wang

Meta Tag

Speaker Ting Wang

Topic Tumor Biology – Preclinical Biology

Keywords

ADRB2

prognostic model

non-small cell lung cancer

NSCLC

immune microenvironment

biomarker

TCGA database

JAK-STAT signaling pathway

therapeutic targets

multi-omics