2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.03B.02 Association of Pre-Existing Conditions with Major Driver Mutations and Immune Contextures in Non-Small Cell Lung Cancer

EP.03B.02 Association of Pre-Existing Conditions with Major Driver Mutations and Immune Contextures in Non-Small Cell Lung Cancer

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The study "Association of Pre-existing Conditions with Major Driver Mutations and Immune Contextures in Non-Small Cell Lung Cancer" by Peiling Chen, conducted at The First Affiliated Hospital of Guangzhou Medical University, explores the relationship between pre-existing conditions and genetic as well as immunological characteristics in non-small cell lung cancer (NSCLC) patients. The study involved 5,507 NSCLC patients who underwent surgical resection, with genetic mutations in nine key oncogenes identified through targeted next-generation sequencing (NGS), and PD-L1 expression assessed in 1,839 of these patients.<br /><br />The key findings include significant correlations between certain pre-existing conditions and specific genetic mutations or immune characteristics. A family history of lung cancer was strongly associated with ROS1 mutations, while a family history of other cancers and hypertension were linked to increased EGFR L858R mutations. Diabetes and hepatitis B surface antigen positivity were found to correlate with EGFR exon 19 deletions, and RhD negativity was associated with BRAF mutations. Additionally, a history of tuberculosis was linked to increased PD-L1 expression in immune cells.<br /><br />The study emphasizes the potential of incorporating patient historical data into the personalization of NSCLC treatment strategies, as these pre-existing conditions might play a role in shaping genetic and immune profiles of the disease. The research calls for further studies to understand the mechanisms behind these associations and their implications for improving clinical practice. The integration of genetic profiling and immune contextures such as PD-L1 expression into treatment approaches continues to advance NSCLC management, with the study highlighting the importance of considering pre-existing conditions in developing personalized treatment plans.

Asset Subtitle

Peiling Chen

Meta Tag

Speaker Peiling Chen

Topic Tumor Biology – Translational Biology

Keywords

non-small cell lung cancer

NSCLC

pre-existing conditions

genetic mutations

immune contextures

targeted next-generation sequencing

PD-L1 expression

personalized treatment

oncogenes

clinical practice