2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.03B.04 Clinicopathological Features of Lung Cancers with RICTOR Gene Amplification

Pdf Summary

In a study by Masato Shono and colleagues, the clinicopathological features of lung cancers with RICTOR gene amplification were examined. The RICTOR gene, a component of the mTOR signaling pathway, is critical in cell survival and proliferation. Although RICTOR gene alterations are noted in various cancers, its amplification in lung cancer as a potential therapeutic target is under-explored. This study aimed to assess the clinicopathological and molecular traits of lung cancer patients with RICTOR gene amplification.<br /><br />A cohort of 142 patients who underwent surgical resection and next-generation sequencing (NGS) between June 2022 and June 2023 was analyzed. Histological subtypes included adenocarcinoma (61%), squamous cell carcinoma (25%), and small cell lung cancer (SCLC) or large cell neuroendocrine carcinoma (LCNEC) (6%).<br /><br />RICTOR gene amplification was identified in 11% of the patients, with its frequency notably high in SCLC/LCNEC (33%), followed by squamous cell carcinoma (11%), and lung adenocarcinoma (9%). Among those with RICTOR amplification, a significant majority were smokers, although other clinical characteristics like age and sex showed no significant differences between patients with and without the amplification.<br /><br />Additionally, RICTOR gene amplification sometimes coexisted with genetic mutations like EGFR, exclusively in adenocarcinoma patients. A higher prevalence of TP53 mutation was observed in patients with RICTOR amplification (60%) compared to those without (47%).<br /><br />The study concludes that RICTOR gene amplification is prevalent in a subset of lung cancers, particularly among smokers and those with SCLC/LCNEC, suggesting a potential focus for targeted therapies in these groups. The co-occurrence with EGFR mutations points to a complexity in genetic interactions worth further investigation, while the association with TP53 mutation requires more exploration to understand its implications.

Asset Subtitle

Masato Shono

Meta Tag

Speaker Masato Shono

Topic Tumor Biology – Translational Biology

Keywords

RICTOR gene amplification

lung cancer

mTOR signaling pathway

clinicopathological features

next-generation sequencing

adenocarcinoma

squamous cell carcinoma

small cell lung cancer

TP53 mutation

EGFR mutation