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2024 World Conference on Lung Cancer (WCLC) - ePos ...
EP.03B.06 EGFR Mutation Prevalence in Non-Lung Can ...
EP.03B.06 EGFR Mutation Prevalence in Non-Lung Cancer Patients
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The study by Nattanan Reungwetwattana aimed to explore the prevalence of EGFR mutations, specifically the Del19 mutation, in lung tissues of non-lung cancer patients. The hypothesis suggests that environmental factors such as PM2.5 could trigger pre-existing EGFR mutations, leading to non-small cell lung cancer (NSCLC). Due to the limited access to lung tissue samples from individuals without lung cancer, this research sought to address this gap.<br /><br />The study involved 175 non-lung cancer patients, with a near-even gender distribution (54% male), a mean age of 56 years, and a smoking history in 19% of participants. Of these patients, 25% had previous cancer diagnoses, including hematologic (11%) and various solid cancers (14%). Tissue samples were gathered from the Pathology Department's archive and analyzed for EGFR mutations using digital PCR. <br /><br />The results revealed that 21% of the samples had the Del19 mutation, with no L858R mutations detected. These findings support the hypothesis of pre-existing EGFR mutations in non-lung cancer populations, potentially linking environmental factors like PM2.5 to oncogenic lung cancer development.<br /><br />The study concludes that the presence of Del19 in non-lung cancer patients suggests a potential pathway for how these pre-existing mutations could be triggered by environmental factors, contributing to oncogenic-driven NSCLC. Further research with a larger cohort at the authors' center aims to explore these findings in more depth and investigate the relationship between environmental triggers and lung cancer pathogenesis.
Asset Subtitle
Nattanan Reungwetwattana
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Speaker
Nattanan Reungwetwattana
Topic
Tumor Biology – Translational Biology
Keywords
EGFR mutations
Del19 mutation
non-lung cancer
environmental factors
PM2.5
NSCLC
digital PCR
oncogenic lung cancer
pathogenesis
Nattanan Reungwetwattana
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