2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.03B.06 EGFR Mutation Prevalence in Non-Lung Cancer Patients

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The study by Nattanan Reungwetwattana aimed to explore the prevalence of EGFR mutations, specifically the Del19 mutation, in lung tissues of non-lung cancer patients. The hypothesis suggests that environmental factors such as PM2.5 could trigger pre-existing EGFR mutations, leading to non-small cell lung cancer (NSCLC). Due to the limited access to lung tissue samples from individuals without lung cancer, this research sought to address this gap.<br /><br />The study involved 175 non-lung cancer patients, with a near-even gender distribution (54% male), a mean age of 56 years, and a smoking history in 19% of participants. Of these patients, 25% had previous cancer diagnoses, including hematologic (11%) and various solid cancers (14%). Tissue samples were gathered from the Pathology Department's archive and analyzed for EGFR mutations using digital PCR. <br /><br />The results revealed that 21% of the samples had the Del19 mutation, with no L858R mutations detected. These findings support the hypothesis of pre-existing EGFR mutations in non-lung cancer populations, potentially linking environmental factors like PM2.5 to oncogenic lung cancer development.<br /><br />The study concludes that the presence of Del19 in non-lung cancer patients suggests a potential pathway for how these pre-existing mutations could be triggered by environmental factors, contributing to oncogenic-driven NSCLC. Further research with a larger cohort at the authors' center aims to explore these findings in more depth and investigate the relationship between environmental triggers and lung cancer pathogenesis.

Asset Subtitle

Nattanan Reungwetwattana

Meta Tag

Speaker Nattanan Reungwetwattana

Topic Tumor Biology – Translational Biology

Keywords

EGFR mutations

Del19 mutation

non-lung cancer

environmental factors

PM2.5

NSCLC

digital PCR

oncogenic lung cancer

pathogenesis

Nattanan Reungwetwattana