2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.03C.01 The Impact of Systemic Inflammatory Markers on EGFR Mutant Non-Small Cell Lung Cancer (NSCLC)

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The study conducted by Supagone Wangsubtawee and colleagues investigates the relationship between systemic inflammatory markers and EGFR-mutant (EGFRm) non-small cell lung cancer (NSCLC). The research highlights the potential role of inflammation in the pathogenesis of EGFRm lung cancer, particularly in the Asian population where there is a high prevalence of this mutation, especially among non-smokers. <br /><br />In this study, 140 patients with resected NSCLC treated from 2016 to 2023 were examined; a significant portion were female (65%), non-smokers (74%), and in stage 1 (64%) of the cancer. These patients underwent lobectomies, and mutations Del19 and L858R were identified using real-time PCR, while NF-Kb and STAT3 protein signaling were measured through ELISA. The prevalence of EGFR mutations in cancer cells was found to be 58%, with NF-Kb and STAT3 signaling proteins significantly higher in cancerous tissues compared to normal tissue. Notably, STAT3 levels were markedly elevated in patients with EGFRm compared to those with wild-type EGFR (EGFRwt).<br /><br />The analysis demonstrated that serum markers such as TNF, IL-10, and STAT3 were higher in patients with EGFRm tumors, but no significant difference in cytokine levels was found between EGFRm and EGFRwt patients overall. STAT3 levels in cancer cells emerged as the primary inflammatory-predictive biomarker that could be associated with EGFRm status alongside non-smoking status.<br /><br />The study suggests that STAT3 has potential as an important inflammatory-predictive biomarker for EGFRm NSCLC, acknowledging the need for larger cohort studies to further validate these findings. This research highlights the intricate link between systemic inflammation and the pathogenesis of EGFR-mutant lung cancer, suggesting pathways for potential therapeutic intervention and personalized treatment strategies for affected patients.

Asset Subtitle

Supagone Wangsubtawee

Meta Tag

Speaker Supagone Wangsubtawee

Topic Tumor Biology – Translational Biology

Keywords

EGFR-mutant

non-small cell lung cancer

systemic inflammation

Asian population

non-smokers

STAT3

NF-Kb

biomarkers

cytokine levels

personalized treatment