2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.03F.05 A Dose-Effect Relationship of a Novel Bronchoscopy Guided Endobronchial Radiofrequency Ablation for Peripheral Lung Tumors

EP.03F.05 A Dose-Effect Relationship of a Novel Bronchoscopy Guided Endobronchial Radiofrequency Ablation for Peripheral Lung Tumors

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The study led by Wonjun Ji at Asan Medical Center investigates a novel approach to treating peripheral lung tumors using bronchoscopy-guided endobronchial radiofrequency ablation (RFA), termed CAROL (Conforming Ablation of Radiofrequency Out of a Liquid Metal). The research focused on evaluating the dose-effect relationship of this procedure utilizing a porcine model. The key aspect of CAROL RFA involves a specially designed balloon catheter and a bronchial electrode using a liquid metal, E-GaIn, to effectively deliver the therapy.<br /><br />The study conducted 22 temperature-time controlled RFA experiments to observe the correlation between the volume of E-GaIn and the resulting ablation zone's diameter. Key results include determining that ablation is effective with an inner bronchus diameter below 3 mm, and E-GaIn volume should ideally be less than 0.5 ml for optimal results. It also noted the importance of maintaining controlled temperature parameters during the process.<br /><br />Furthermore, the study successfully ablated all test tumors in a pseudotumor model, with an average tumor diameter of 14.4 mm resulting in an ablation zone of 31.2 mm. This consistency shows the process's capability for potentially effective tumor reduction.<br /><br />Conclusions drawn from the study suggest that the CAROL RFA method demonstrates a promising dose-effect relationship, indicating its potential for clinical application in human patients. These findings advocate for further research and consideration for use in human medical contexts, offering a new avenue for treating peripheral lung tumors with precision and control.

Asset Subtitle

Wonjun Ji

Meta Tag

Speaker Wonjun Ji

Topic Tumor Biology – Translational Biology

Keywords

bronchoscopy

endobronchial radiofrequency ablation

CAROL

peripheral lung tumors

liquid metal

E-GaIn

porcine model

tumor ablation

clinical application

dose-effect relationship