2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.03G.02 Molecular and Immune Landscape of Invasive Mucinous Adenocarcinoma (IMA) Of the Lung and Its Survival Outcome

EP.03G.02 Molecular and Immune Landscape of Invasive Mucinous Adenocarcinoma (IMA) Of the Lung and Its Survival Outcome

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In this study, researchers led by Seoin Kim from Northwestern University Feinberg School of Medicine examined the molecular and immune characteristics of invasive mucinous adenocarcinoma (IMA) of the lung, comparing it to non-IMA lung adenocarcinomas. The study utilized de-identified records from the Tempus database, encompassing a cohort of 699 IMA patients and 19,372 non-IMA patients.<br /><br />Key findings of the research reveal that IMA is a rare subset of lung adenocarcinomas, often diagnosed at an earlier stage but associated with poorer overall survival compared to non-IMA cases. The study found that IMA patients had a lower tumor mutational burden and a reduced frequency of PD-L1 positive statuses. In the tumor microenvironment of IMA patients, there was a notable presence of immunosuppressive cells like M2 macrophages and regulatory T cells (Tregs), and a reduction in CD8 T cells and M1 macrophages, which potentially contributes to poor responses to immunotherapy.<br /><br />Gene expression analysis identified upregulation of immunosuppressive and mucin-related genes in IMA, implicating these in immune evasion strategies. The study also highlighted certain demographic and clinical differences: IMA patients had a lower rate of smoking, and the study found a higher proportion of Hispanic/Latino individuals among them.<br /><br />The research underscores the unique pathological and immunological features of IMA, suggesting these differences may play a role in the prognosis and therapeutic strategies for treating this specific cancer type. The insights gained call for further investigation into tailored treatment approaches for IMA, considering its distinct molecular landscape.

Asset Subtitle

Seoin Kim

Meta Tag

Speaker Seoin Kim

Topic Tumor Biology – Translational Biology

Keywords

invasive mucinous adenocarcinoma

lung cancer

molecular characteristics

immune characteristics

tumor microenvironment

immunotherapy

gene expression

demographic differences

prognosis

therapeutic strategies