2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.04A.11 Patients Reported Outcomes in Short- And Long-Term Lung Cancer Survivors Who Were Diagnosed via Chest Low-Dose CT Screening

EP.04A.11 Patients Reported Outcomes in Short- And Long-Term Lung Cancer Survivors Who Were Diagnosed via Chest Low-Dose CT Screening

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This study, conducted by the Mayo Clinic and other international hospitals, investigates the quality of life (QoL) outcomes in lung cancer patients diagnosed via chest low-dose computed tomography (LDCT) screening compared to those diagnosed through usual care, as well as controls who screened negative. It seeks to fill the gap in understanding the long-term effects of LDCT screening on patients' health and psychosocial well-being.<br /><br />The research analyzed a 20-year cohort of 4,122 patients who completed Patient Reported Outcomes (PRO) questionnaires within three years of diagnosis (short-term respondents) and 1,291 patients who completed them five years post-diagnosis (long-term respondents). The study tracks factors impacting QoL, such as fatigue, social activity, and dyspnea, and evaluates them on a scale from 0 (worst) to 10 (best), with clinically meaningful differences marked by shifts of 1.0 unit or more.<br /><br />For short-term responders, CT-screened patients had more positive outcomes in several aspects, including appetite and general activity, compared to those diagnosed via usual care. Similarly, both CT-screened patients and controls reported better overall quality of life compared to usual-care-diagnosed patients. In terms of long-term observations, CT-screened patients demonstrated similar differences in disease stage and treatment modality.<br /><br />A persistent burden noted across all patient groups was dyspnea and fatigue, highlighting the need for targeted interventions. Regardless of diagnosis method, participants reported strong support from family and friends and consistent spiritual, financial, and legal concerns.<br /><br />The findings suggest that LDCT screening correlates with better short-term QoL outcomes but maintains the same challenges related to persistent lung cancer symptoms over the long term, as experienced by both CT-screened and usual-care-diagnosed patients.

Asset Subtitle

Kexin Tan

Meta Tag

Speaker Kexin Tan

Topic Screening and Early Detection

Keywords

lung cancer

quality of life

LDCT screening

Mayo Clinic

Patient Reported Outcomes

dyspnea

fatigue

psychosocial well-being

disease stage

treatment modality