2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.04A.16 Cost-Effectiveness of Adaptive Schedules for Lung Cancer Screening: A Modeling Study

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This modeling study evaluated the cost-effectiveness of adaptive lung cancer screening schedules compared to regular screening strategies for individuals from the 1960 US birth cohort. As lung cancer is one of the costliest cancers in the US, understanding cost-effective screening strategies is crucial. The research was conducted by Pianpian Cao, Jihyoun Jeon, and Rafael Meza from various health departments across the US and Canada.<br /><br />The study compared adaptive schedules, designed based on individual characteristics and past screening results, with standard annual, biennial, and triennial screenings using a deterministic threshold approach that calculates the probability of preclinical disease states. The researchers considered various cost factors, health utilities, and the disutility of screening, performing one-way and probabilistic sensitivity analyses to assess the impact of these parameters on cost-effectiveness.<br /><br />The study's findings indicate that individualized adaptive screening schedules provide a favorable benefit-to-harm ratio compared to annual screening. While annual lung cancer screening had an incremental cost-effectiveness ratio (ICER) of $270,000 per quality-adjusted life year (QALY), adaptive schedules became more cost-effective, especially under scenarios of high screening disutility. The most effective adaptive strategy, characterized by a 0.15% risk threshold, had an ICER of $98,513, making it the only strategy below the $100,000 willingness-to-pay (WTP) threshold.<br /><br />The study underscores the potential advantages of personalized screening strategies over traditional methods, suggesting that adaptive schedules could be a viable method for maximizing lung cancer screening effectiveness while minimizing costs. The research was supported by the National Cancer Institute and is part of ongoing efforts to refine cancer screening guidelines.

Asset Subtitle

Pianpian Cao

Meta Tag

Speaker Pianpian Cao

Topic Screening and Early Detection

Keywords

adaptive lung cancer screening

cost-effectiveness

US birth cohort 1960

individualized schedules

deterministic threshold approach

quality-adjusted life year

incremental cost-effectiveness ratio

personalized screening

National Cancer Institute

cancer screening guidelines