2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.04B.02 Identification of Circulating MicroRNAs Associated with Lung Cancer Diagnosis and Progression

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The document titled "Identification of Circulating MicroRNAs Associated with Lung Cancer Diagnosis and Progression" explores the role of microRNAs (miRNAs) as potential biomarkers for early lung cancer detection and monitoring disease progression. The study involves several key contributors from Japan, Singapore, and the USA. Researchers collected plasma samples from 50 patients at various stages around surgery—before (M0), and three and six months post-surgery (M3, M6). They measured the levels of 362 miRNAs using advanced technology and performed data processing that included normalization and pair-wise analysis to identify differentially expressed (DE) miRNAs.<br /><br />The findings reveal that several miRNAs display significant changes in expression post-surgery and could be linked to cancer pathways, with a particular focus on the miRNA hsa-miR-339-5p, which showed elevated levels post-surgery and varied expression across different cancer stages. This miRNA is highlighted as a potential early detection marker and monitor for stage progression.<br /><br />Pathway analysis through KEGG revealed that various oncogenic pathways, including those involved in axon guidance and signaling routes like Hippo, cancer pathways, and Ras signaling, are influenced by these miRNAs. The study emphasizes the importance of miRNAs in tumor suppression and their potential application in lung cancer's biological landscape.<br /><br />The research highlights the need for continued work to validate these miRNAs as biomarkers in larger cohorts and to explore the specific genes and pathways they affect. This study underscores the critical need for enhanced diagnostic methods in lung cancer due to the limitations of current imaging technologies and portrays miRNAs as promising tools for improving early detection and tailored therapeutic strategies.

Asset Subtitle

Joji Samejima

Meta Tag

Speaker Joji Samejima

Topic Screening and Early Detection

Keywords

microRNAs

lung cancer

biomarkers

early detection

disease progression

hsa-miR-339-5p

oncogenic pathways

tumor suppression

diagnostic methods

therapeutic strategies