2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.04C.01 The Value of Ultrahigh Frequency Ultrasound in Localizing Small Pulmonary Ground Glass Opacity Intraoperatively: A Prospective Study

EP.04C.01 The Value of Ultrahigh Frequency Ultrasound in Localizing Small Pulmonary Ground Glass Opacity Intraoperatively: A Prospective Study

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The document outlines a prospective observational study investigating the effectiveness of Ultrahigh-Frequency Ultrasound (UHFUS) in intraoperative localization of ground glass opacities (GGOs) in lung tissues. GGOs, indicative of early-stage lung cancer, have become more frequently detected, with precise intraoperative localization, particularly for small GGOs, posing significant challenges.<br /><br />Conducted between June 2023 and March 2024, the study involved 36 patients with 58 GGOs undergoing surgical procedures. UHFUS, operating at frequencies of 22-38 MHz, was used alongside palpation techniques to localize GGOs in excised lung tissues. Two radiologists independently evaluated the UHFUS features.<br /><br />Results demonstrated that UHFUS significantly outperformed palpation in localization rates, particularly for small nodules and pure GGOs. For micronodules (≤ 5 mm), UHFUS achieved a 100% localization rate compared to the 80% achieved by palpation. Additionally, UHFUS offered a notably reduced localization time, making it more efficient for surgical procedures. UHFUS could also detect new GGOs intraoperatively.<br /><br />The imaging characteristics of GGOs were predominantly indistinct hypoechoic areas with posterior shadowing, and the agreement in diameter measurement between UHFUS-pathology was found to be superior to that of CT-pathology. This demonstrates UHFUS's capability as a promising, real-time, non-invasive, and radiation-free strategy for GGOs localization in surgery. It enhances the surgical process efficiency and holds the potential to identify previously undetected nodules.<br /><br />In conclusion, UHFUS significantly improves localization accuracy and efficiency over traditional palpation methods, advocating for its application as an innovative intraoperative localization tool for GGOs. The study supports UHFUS as a novel technique with real-time capabilities, promising enhancements in the surgical management of early-stage lung cancer.

Asset Subtitle

Xuehan Gao

Meta Tag

Speaker Xuehan Gao

Topic Screening and Early Detection

Keywords

Ultrahigh-Frequency Ultrasound

UHFUS

ground glass opacities

GGOs

lung cancer

intraoperative localization

surgical procedures

micronodules

non-invasive

real-time imaging