2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.04E.05 Prevalence and Characterization of MET Overexpression in Chinese NSCLC Patients: A Retrospective Real-World Analysis

EP.04E.05 Prevalence and Characterization of MET Overexpression in Chinese NSCLC Patients: A Retrospective Real-World Analysis

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The study titled "Prevalence and Characterization of MET Overexpression in Chinese NSCLC Patients: A Retrospective Real-World Analysis" was conducted by researchers from the First Affiliated Hospital of Wenzhou Medical University, China. It aimed to explore the characteristics of MET overexpression in non-small cell lung cancer (NSCLC) patients and its potential as a therapeutic target.<br /><br />The analysis included 1,223 patients between June 2020 and August 2023, with 87 patients showing MET overexpression. The study found a 7% detection rate for MET positivity, characterized by an intensity level of 3. MET overexpression was more prevalent in males (70.1%), adenocarcinomas (81.6%), stage IV cancer patients (69.0%), and those with concomitant hypertension (39.1%).<br /><br />Different treatment regimens were employed, including chemotherapy, chemotherapy with immune checkpoint inhibitors, and targeted therapy. A notable correlation was found between MET overexpression and anemia, indicated by decreased red blood cells (correlation coefficient -0.3139, p=0.0036) and hemoglobin levels (correlation coefficient -0.3805, p=0.0002).<br /><br />While the study provides insights into the prevalence and characteristics of MET overexpression, it mentions a limited follow-up period, resulting in a lack of progression-free survival (PFS) data for these patients.<br /><br />The study suggests that MET overexpression may contribute to anemia and highlights the potential of MET as a target for future research in NSCLC treatment, with significant occurrences observed in male patients, those with adenocarcinomas, and at an advanced stage of cancer. This research lays the groundwork for future investigations and potential therapeutic developments targeting MET in NSCLC.

Asset Subtitle

Li Yang

Meta Tag

Speaker Li Yang

Topic Screening and Early Detection

Keywords

MET overexpression

NSCLC

non-small cell lung cancer

Chinese patients

adenocarcinoma

anemia correlation

therapeutic target

real-world analysis

Wenzhou Medical University

targeted therapy