2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.04E.06 The Prediction of Spread Through Air Spaces with Preoperative 18F-FDG PET/CT in Clinical Stage I Lung Cancer

EP.04E.06 The Prediction of Spread Through Air Spaces with Preoperative 18F-FDG PET/CT in Clinical Stage I Lung Cancer

Pdf Summary

The study titled "The Prediction of Spread Through Air Spaces with Preoperative 18F-FDG PET/CT in Clinical Stage I Lung Cancer" conducted by researchers at Ankara University investigated the ability of preoperative 18F-FDG PET/CT imaging to predict the presence of spread through air spaces (STAS) in clinical stage I lung cancer patients. STAS is known to be associated with local recurrence, especially after limited resections like segmentectomy or wedge resection, and is typically evaluated postoperatively through histopathological examination. The study aimed to determine if preoperative PET/CT data could predict STAS and thereby assist in surgical decision-making.<br /><br />This retrospective study analyzed 205 patients with stage I lung cancer who had undergone surgery without prior neoadjuvant treatment. The researchers assessed maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) from preoperative PET/CT scans. Patients were divided into STAS absent and present groups, and the PET/CT parameters were compared using statistical tests.<br /><br />Results showed that 82.4% of tumors were FDG avid, and differences in SUVmax and SUVmean values were statistically significant between STAS positive and negative cases, with higher values associated with STAS presence. In contrast, MTV and TLG did not show significant differences. The SUVmax, in particular, demonstrated notable diagnostic performance, suggesting it could help predict STAS and guide the type of resection required. Hence, the study concludes that preoperative 18F FDG-PET/CT, and especially SUVmax and SUVmean, may be useful in predicting STAS in stage I lung cancer patients to optimize surgical strategies.

Asset Subtitle

Yusuf Kahya

Meta Tag

Speaker Yusuf Kahya

Topic Screening and Early Detection

Keywords

STAS

18F-FDG PET/CT

stage I lung cancer

preoperative imaging

SUVmax

SUVmean

surgical decision-making

local recurrence

retrospective study

surgical strategies