2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.05A.02 Timing of PET-CT has no Significant Impact on Staging EBUS Results in Mediastinal Staging and Diagnosis of Lung Cancer

EP.05A.02 Timing of PET-CT has no Significant Impact on Staging EBUS Results in Mediastinal Staging and Diagnosis of Lung Cancer

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The study, led by Dr. Vytis Dudzevičius and colleagues from James Cook University Hospital, investigates the timing of Positron Emission Tomography-Computed Tomography (PET-CT) in relation to endobronchial ultrasound (EBUS) sampling for mediastinal staging and diagnosis of lung cancer. The research aims to determine whether the order of these diagnostic procedures impacts the accuracy of staging in patients with suspected lung cancer.<br /><br />Guidelines from the National Institute for Health and Care Excellence suggest performing a PET-CT followed by EBUS to enhance diagnostic precision. While PET-CT alone may lack sufficient sensitivity and specificity, combining it with EBUS aids in delineating radiotherapy fields and potentially reduces the need for repeat biopsies.<br /><br />The study involved 59 patients with suspected lung cancer and mediastinal lymphadenopathy. The patients were split into two groups: one where EBUS was conducted before PET-CT and another where PET-CT preceded EBUS. The results compared lymph nodes' histological findings or visual EBUS assessments to fluorodeoxyglucose uptake on PET-CT, with findings analyzed for agreement or discordance.<br /><br />Findings indicated no significant impact of PET-CT timing on EBUS results for mediastinal staging, with similar staging accuracy observed whether PET-CT was performed before or after EBUS. Concordance between EBUS and PET-CT findings was higher for cancerous conditions compared to benign ones. PET-CT remains necessary for evaluating nodes that are inaccessible via EBUS and for detecting metastatic diseases in lung cancer patients.<br /><br />In conclusion, EBUS is a valuable diagnostic tool for mediastinal staging independent of PET-CT timing. PET-CT supports identifying nodes beyond EBUS's reach. The data point toward the integration of both methods in clinical practice for comprehensive evaluation of suspected lung cancer cases.

Asset Subtitle

Vytis Dudzevicius

Meta Tag

Speaker Vytis Dudzevicius

Topic Pulmonology and Staging

Keywords

lung cancer

PET-CT

EBUS

mediastinal staging

diagnostic procedures

lymphadenopathy

radiotherapy fields

biopsy

sensitivity

specificity