2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.05A.08 The Accuracy of Bronchoscopy and Transthoracic Needle Biopsy for Diagnosing Lung Cancer

EP.05A.08 The Accuracy of Bronchoscopy and Transthoracic Needle Biopsy for Diagnosing Lung Cancer - A Systematic Review

Pdf Summary

The abstract "#3080" from a systematic review assesses the diagnostic accuracy of bronchoscopy and transthoracic needle biopsy (TTNB) for lung cancer (LC) diagnosis. The research is a collaborative effort among multiple Brazilian institutions, spearheaded by Eldsamira Mascarenhas and collaborators.<br /><br />Lung cancer, a leading cause of cancer-related deaths, necessitates an accurate diagnosis for effective treatment planning. This review gathers clinical data to evaluate the effectiveness of two biopsy techniques: bronchoscopy and TTNB.<br /><br />Key findings indicate that CT-guided TTNB exhibits a high diagnostic accuracy, particularly for peripheral lung nodules. It reports a pooled sensitivity of 0.90 and specificity of 0.96, with a summary receiver operating characteristic (sROC) of 0.95. The positive likelihood ratio (LR) is 30.6, and the negative likelihood ratio (LR-) is 0.09, with a diagnostic odds ratio (DOR) of 314, based on data from 4,606 patients over 20 studies.<br /><br />The study highlights weaknesses in bronchoscopy, noting a scarcity of primary studies on its diagnostic accuracy, which impedes comprehensive meta-analysis. Its variable effectiveness in detecting premalignant lesions underscores the need for improved non-invasive biopsy modalities.<br /><br />Despite TTNB's impressive metrics, the analysis acknowledges a 5%-12% false-negative rate due to factors like lesion size, needle gauge, and operator skill, necessitating result confirmation through other diagnostic methods, including bronchoscopy.<br /><br />The review concludes that while TTNB is effective, it does not eliminate the need for invasive procedures, and enhanced techniques are needed for bronchoscopy's diagnostic precision.<br /><br />Acknowledgments are extended to various contributors and pharmaceutical companies for their support in this study.

Asset Subtitle

Eldsamira Mascarenhas

Meta Tag

Speaker Eldsamira Mascarenhas

Topic Pulmonology and Staging

Keywords

bronchoscopy

transthoracic needle biopsy

lung cancer diagnosis

CT-guided TTNB

diagnostic accuracy

sensitivity and specificity

systematic review

diagnostic odds ratio

false-negative rate

non-invasive biopsy