2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.06B.04 Aging Alteration of Biomarkers and Its Prognostic Role in Elderly Lung Cancer Patients Treated with Adjuvant S-1 Chemotherapy

EP.06B.04 Aging Alteration of Biomarkers and Its Prognostic Role in Elderly Lung Cancer Patients Treated with Adjuvant S-1 Chemotherapy

Back to course

Pdf Summary

The study investigates age-related changes in biomarkers and their prognostic significance for elderly non-small cell lung cancer (NSCLC) patients undergoing adjuvant S-1 chemotherapy. S-1 is an oral chemotherapy agent effective in elderly patients when administered daily or on alternate days after surgical resection. This research analyzes gene expression, particularly six biomarkers (TS, TP, DPD, OPRT, ERCC1, and EGFR), using The Cancer Genome Atlas (TCGA) datasets.<br /><br />The findings reveal that thymidylate synthetase (TS) expression decreases significantly with age, while dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP) expression increase. This change suggests that 5-FU treatment outcomes might vary with age. The study enrolled 89 patients from the Setouchi Lung Cancer Group (SLCG) 1201 trial, analyzing their mRNA expression levels through quantitative PCR and performing statistical evaluations, including survival analyses.<br /><br />Key results indicate high expression of EGFR and DPD genes, and low expression of ERCC1 and TS genes, associate notably with EGFR mutations. Univariate analysis shows low EGFR expression correlates with worse recurrence-free survival (RFS), while high TS expression correlates with poorer overall survival (OS). Multivariate analysis identifies advanced pathological stage (II/III) as an independent adverse prognostic factor for both RFS and OS.<br /><br />The study concludes that the age-related decline in TS expression supports the potential efficacy of 5-FU-based treatments in elderly NSCLC patients. It emphasizes the necessity for further investigations, particularly considering pathological stages and the expressions of EGFR and TS as predictors for better clinical outcomes in these patients. Despite these findings, high EGFR and low TS expressions may indicate favorable outcomes for those treated with adjuvant S-1 therapy.

Asset Subtitle

Junichi Soh

Meta Tag

Speaker Junichi Soh

Topic Pathology and Biomarkers

Keywords

age-related changes

biomarkers

NSCLC

S-1 chemotherapy

gene expression

EGFR mutations

5-FU treatment

survival analysis

prognostic factors

elderly patients