2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.06B.06 A Meta-Analysis of Advanced Lung Index (ALI) in Advanced Lung Cancer Patients

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This meta-analysis, conducted by researchers from the University of Texas Health Science Center, evaluated the prognostic significance of the Advanced Lung Index (ALI) in patients with advanced lung cancer. The study explored the relationship between pre-treatment ALI values and patient outcomes, focusing on overall survival (OS) and progression-free survival (PFS). ALI is calculated as body mass index (BMI) multiplied by albumin (ALB) divided by the neutrophil-lymphocyte ratio (NLR), and it has been identified as a prognostic indicator across various cancer types.<br /><br />Data from nine articles related to advanced lung cancer were analyzed using a random-effects model to calculate pooled hazard ratios for OS and PFS. The results established that higher pre-treatment ALI values were significantly associated with increased overall survival. Specifically, univariable hazard ratios (HR) indicated a strong link (HR 1.94, 95% CI 1.68-2.23), and this association was marginally weaker but still significant in multivariable analyses (HR 1.57, 95% CI 1.37-1.79). Unfortunately, an analysis on progression-free survival was not possible due to limited data.<br /><br />The study also examined the variability in ALI cutoff values, which ranged from 18 to 47 across the studies. It identified a marginally significant relationship between these cutoff values and the hazard ratios, suggesting that values above 40 were associated with better survival outcomes, while those below 20 indicated poorer survival.<br /><br />In conclusion, the analysis confirms that high ALI values correlate with longer survival in advanced lung cancer cases. It highlights the need to adopt a three-tier classification system for ALI values, ranging from low to high, to better guide prognosis and potential clinical applications for these patients.

Asset Subtitle

Kok Hoe Chan

Meta Tag

Speaker Kok Hoe Chan

Topic Pathology and Biomarkers

Keywords

meta-analysis

Advanced Lung Index

prognostic significance

lung cancer

overall survival

progression-free survival

body mass index

hazard ratios

three-tier classification

University of Texas