2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.06E.08 Clinical Significance of JPH4 and Correlation with the Immune Microenvironment of Lung Adenocarcinoma

EP.06E.08 Clinical Significance of JPH4 and Correlation with the Immune Microenvironment of Lung Adenocarcinoma

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This study investigates the role of the JPH4 gene in lung adenocarcinoma (LUAD), focusing on its expression levels, correlation with clinicopathological parameters, and its effects on the tumor microenvironment. Despite advancements in targeted and immunotherapies for non-small cell lung cancer (NSCLC), including LUAD, patient survival rates remain low. Thus, identifying new prognostic markers and therapeutic targets is crucial.<br /><br />The research utilized various bioinformatics tools and databases, including TIMER, GEPIA, and TCGA, alongside experimental methods like qPCR, Western blot, and immunohistochemistry, to analyze JPH4 expression in LUAD tissues compared to normal tissues. Key findings demonstrated aberrant expression of JPH4 in LUAD, suggesting its significant involvement in modulating the tumor microenvironment, particularly enhancing anti-tumor immune cell infiltration. This regulation is believed to suppress LUAD progression, indicating JPH4's role in anti-tumor immunity.<br /><br />Importantly, the study suggests JPH4 might serve as an independent prognostic biomarker and potential therapeutic target for LUAD. Its differential expression correlates with various clinical subgroups and immune cell infiltration, underscoring its clinical significance. The research proposes that further exploration into how JPH4 impacts the immune landscape of tumors could provide novel insights, potentially refining immunotherapeutic approaches for LUAD patients.<br /><br />The authors recommend future studies should incorporate animal and cell experiments to explore the mechanistic pathways by which JPH4 influences the tumor microenvironment. This research is supported by the National Natural Science Foundation of China, highlighting an ongoing commitment to improving outcomes for LUAD patients through innovative biomedical research.

Asset Subtitle

Jia Feng

Meta Tag

Speaker Jia Feng

Topic Pathology and Biomarkers

Keywords

JPH4 gene

lung adenocarcinoma

tumor microenvironment

prognostic biomarker

immune cell infiltration

bioinformatics tools

therapeutic target

NSCLC

anti-tumor immunity

gene expression