2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.06F.02 Enhancing Clinical Utility: Oncomine Dx Target Test Augments Biomarker Detection in Advanced Non-Small-Cell Lung Cancer

EP.06F.02 Enhancing Clinical Utility: Oncomine Dx Target Test Augments Biomarker Detection in Advanced Non-Small-Cell Lung Cancer

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The study conducted by Tae-Jung Kim at Yeouido St. Mary’s Hospital in Korea investigates the integration of the Oncomine Dx Target Test (ODxTT) with single gene tests (SGTs) in diagnosing advanced non-small-cell lung cancer (NSCLC). Despite advancements in targeted therapies, challenges persist regarding the use of single gene tests alongside next-generation sequencing (NGS) due to tissue limitations and reimbursement issues.<br /><br />The research analyzed the effects of ODxTT integration by evaluating three cohorts over three years. Cohort 1, which included 458 patients, utilized a combination of ODxTT and SGTs. Cohorts 2 and 3, consisting of 1,850 and 1,968 patients respectively, relied solely on SGTs. All cohorts underwent tests for mutations in genes like EGFR, ALK, and ROS1.<br /><br />Findings indicate that pairing ODxTT with SGTs provides significant additional diagnostic information without sacrificing the effectiveness of SGTs. The ODxTT's high success rate in detecting mutations suggests that integrating this test could broaden therapeutic strategies for advanced NSCLC, offering a more comprehensive approach to treatment. <br /><br />Furthermore, the study highlights the ODxTT's ability to detect a variety of gene mutations across different cancer types, which could lead to more targeted and effective treatments. Through expanded biomarker detection, clinicians can make more informed decisions about patient-specific therapeutic options, ultimately enhancing patient care. <br /><br />Overall, the integration of ODxTT within clinical practice represents a promising advancement in the molecular diagnostics of lung cancer, supporting the development of personalized medicine approaches for patients with advanced NSCLC.

Asset Subtitle

Tae-Jung Kim

Meta Tag

Speaker Tae-Jung Kim

Topic Pathology and Biomarkers

Keywords

Oncomine Dx Target Test

single gene tests

non-small-cell lung cancer

NSCLC

next-generation sequencing

gene mutations

personalized medicine

biomarker detection

therapeutic strategies

molecular diagnostics