2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.06F.08 Cancer Evolution Analysis for Lung Carcinomas with Multiple Driver Mutations

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The study presented at the 2024 WCLC E-Poster focused on understanding the evolution of lung carcinomas with multiple driver mutations. Despite driver mutations generally being considered mutually exclusive, 17 cases of tumors with multiple mutations were identified from 1,906 surgical resections between 2017 and 2023 at Aichi Cancer Center Hospital. The study utilized RNA sequencing and other analyses to investigate these tumors.<br /><br />Of the 17 cases (ages 55-81, with a majority being females), 82% were adenocarcinomas. Common mutations found included EGFR (76%) and KRAS (76%), with some tumors exhibiting up to three mutations. The findings indicated that while EGFR mutations are prevalent in the Asian population's NSCLCs, KRAS mutations were notably frequent in cases with multiple driver mutations.<br /><br />Panel sequencing of six cases highlighted the complexity of determining dominant mutations, as no specific trend was observed. These analyses revealed that mutations like MET exon 14 skipping contribute significantly to carcinogenesis and progression, unlike KRAS p.G12S, which didn’t appear to influence cancer progression in the cases studied.<br /><br />The research suggested that multiple mutations in a single tumor could be more common than previously understood, with histological diversity indicating possible cases of collision carcinoma. The report emphasized the importance of increasing the number of RNA-sequenced cases and utilizing single-cell analysis for more precise insights into tumor evolution.<br /><br />Conclusively, the study shed light on the complexities and potential co-occurrence of driver mutations in NSCLC, specifically highlighting the interplay between EGFR, KRAS, and other mutations, and underscoring the necessity for further investigation into how these mutations coexist and contribute to lung carcinoma progression.

Asset Subtitle

Katsutoshi Seto

Meta Tag

Speaker Katsutoshi Seto

Topic Pathology and Biomarkers

Keywords

lung carcinomas

driver mutations

EGFR

KRAS

RNA sequencing

adenocarcinomas

MET exon 14 skipping

collision carcinoma

NSCLC

tumor evolution