2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.06G.17 A Clinical Conundrum: Lung Cancer in the Breast

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The study conducted a comprehensive review of lung cancer cases with breast metastasis, exploring a vast array of published case studies from the years 1962 to 2024. Researchers extracted data from the PubMed database using specific keywords related to lung cancer and breast metastasis. From an initial pool of 3,268 unique articles, 359 full manuscripts were examined, and 84 were found to meet the stringent inclusion criteria, resulting in 146 patient cases being analyzed.<br /><br />The study focused on patient demographics, clinical and disease characteristics, tumor immunohistochemistry, biomarker profiles, disease management strategies, and corresponding clinical outcomes, with a detailed summary provided in Table 1 of the study. In terms of cancer type, lung adenocarcinoma was observed as the most prevalent type leading to breast metastasis. A notable finding was that 50% of the patients had metachronous metastatic breast disease, identified on average 24 months following the initial lung cancer diagnosis. The bone was the most frequent additional site of metastatic disease, observed in 32 out of 75 patients (42.7%).<br /><br />Immunohistochemical testing results indicated high percentages of breast metastases retaining lung origin markers, with 86.5% showing TTF1 positivity and 91.8% testing positive for CK7. Various molecular markers were evaluated, revealing EGFR mutations in 55.6% of cases, ALK rearrangement in 35.3%, and ROS1 positivity in 60%.<br /><br />This extensive review highlights the complexity of distinguishing between primary breast cancer and metastasis from primary lung cancer, emphasizing the unique clinical features and the critical role of precise pathological and molecular assessments in guiding appropriate treatment decisions for these uncommon metastatic presentations.

Asset Subtitle

Jonathan Nakata

Meta Tag

Speaker Jonathan Nakata

Topic Pathology and Biomarkers

Keywords

lung cancer

breast metastasis

adenocarcinoma

immunohistochemistry

biomarker profiles

metachronous metastasis

TTF1 positivity

EGFR mutations

ALK rearrangement

ROS1 positivity