2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.06G.20 Advanced Squamous Cell Lung Carcinoma in Never Smokers: A Different Entity? Analysis from the Thoracic Tumor Registry in Spain (RTT)

EP.06G.20 Advanced Squamous Cell Lung Carcinoma in Never Smokers: A Different Entity? Analysis from the Thoracic Tumor Registry in Spain (RTT)

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The study conducted by the Thoracic Tumor Registry in Spain explored the characteristics and outcomes of advanced squamous cell lung carcinoma (SQCLC) in individuals who have never smoked. Traditionally associated with a history of smoking, SQCLC can also occur in non-smokers, but its prevalence is rare and less understood, particularly outside of Asian populations.<br /><br />A total of 2351 patients with advanced SQCLC were analyzed, among which 100 were non-smokers. The study aimed to identify any distinct clinical, epidemiological, and molecular characteristics in non-smokers compared to current or former smokers. Key observations from the study include:<br /><br />1. **Demographics**: Non-smokers were more frequently women (63%) and had a history of cancer (26%) compared to smokers (12.1% and 17.1%, respectively). The median age was similar for both groups (around 68 years).<br /><br />2. **Clinical Presentation**: Non-smokers were more likely to have subcutaneous, extrathoracic lymph nodes, and central nervous system metastases compared to smokers. However, no significant differences were noted regarding occupational exposures or performance status at diagnosis.<br /><br />3. **Treatment and Survival**: Both groups received similar types of treatments and amounts of local treatment. There were no notable differences in progression-free survival (PFS) or overall survival (OS) between the two groups, with median PFS of 5.7 months for non-smokers and 5.5 months for smokers, and median OS of about 10-11 months for both groups.<br /><br />4. **Molecular Characteristics**: More extensive molecular analyses, including PDL1, were performed more frequently on non-smokers, but the study could not identify significant molecular differences between non-smokers and smokers, possibly due to varied gene analysis methods.<br /><br />The study concludes that more research is necessary to comprehensively understand the unique molecular characteristics of SQCLC in non-smokers. Despite demographic differences, survival outcomes and treatment responses appear consistent across both smoker and non-smoker groups.

Asset Subtitle

Virginia Calvo

Meta Tag

Speaker Virginia Calvo

Topic Pathology and Biomarkers

Keywords

Thoracic Tumor Registry

advanced squamous cell lung carcinoma

non-smokers

clinical characteristics

epidemiological characteristics

molecular characteristics

treatment outcomes

survival analysis

PDL1 analysis

Spain