2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.07A.03 Influence of Preoperative Percutaneous Transthoracic Lung Biopsy on Recurrence and Mortality after Surgery for Lung Cancer

EP.07A.03 Influence of Preoperative Percutaneous Transthoracic Lung Biopsy on Recurrence and Mortality after Surgery for Lung Cancer

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The study presented by Eui Jin Hwang from Seoul National University Hospital investigates the association between preoperative percutaneous transthoracic needle biopsy (PTNB) and postoperative recurrence and mortality among lung cancer patients in Korea. PTNB is a commonly used diagnostic procedure for lung lesions with a risk of malignancy but comes with notable complications like pneumothorax and rare long-term issues such as tumor implantation along the needle track.<br /><br />The research utilizes data from the Korea Central Cancer Registry, comprising 13,929 new lung cancer cases from 2014 to 2018. The study focuses on 3,389 patients who underwent curative surgery for non-small cell lung cancer (NSCLC), excluding those with incomplete data, multiple primary tumors, and certain treatment histories.<br /><br />Statistical analyses, specifically restricted mean survival time (RMST), explored the impact of PTNB on outcomes such as time-to-recurrence, lung cancer-specific survival, and overall survival. It further assessed how these associations varied by disease stage and histopathological type.<br /><br />Key findings revealed that preoperative PTNB was linked to a higher risk of recurrence, lung cancer-specific mortality, and overall mortality, notably in Stage I NSCLC and adenocarcinoma patients. These adverse outcomes highlight the need for careful consideration regarding the use of PTNB in patients with resectable lung cancer.<br /><br />Limitations of the study include unavailable data on recurrence patterns and potential confounding factors like radiologic features and histopathologic subtypes. The research underscores the importance of weighing the risks and benefits before conducting PTNB to avoid increased postoperative complications.

Asset Subtitle

Eui Jin Hwang

Meta Tag

Speaker Eui Jin Hwang

Topic Early-Stage Non-small Cell Lung Cancer

Keywords

preoperative PTNB

lung cancer

postoperative recurrence

mortality

NSCLC

adenocarcinoma

Korea Central Cancer Registry

restricted mean survival time

Stage I lung cancer

tumor implantation