2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.07A.15 Prognosis after Surgical Treatment of Lung Cancer with Multifocal Ground-Glass Nodules: The Effect of Nodule Characteristics

EP.07A.15 Prognosis after Surgical Treatment of Lung Cancer with Multifocal Ground-Glass Nodules: The Effect of Nodule Characteristics

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This study investigates the prognosis following surgical treatment of lung cancer involving multifocal ground-glass nodules (GGNs), focusing on how the characteristics of these nodules affect long-term outcomes. The management of GGNs in lung cancer presents a challenge due to the heterogeneity in nodule characteristics and distribution.<br /><br />**Methods:** The research included 284 patients who underwent pulmonary resection for lung cancer with synchronous multifocal GGNs from 2013 to 2019. Patients were categorized based on the radiologic consolidation-tumor ratio (CTR) of the dominant nodule into three groups: PSN-1 (CTR<0.5), PSN-2 (0.5≤CTR<1), and Solid (CTR≥1). The study compared overall survival and disease-free survival among these groups.<br /><br />**Findings:** The patient cohort was composed of a higher proportion of females (60.2%) and never-smokers (67.3%). A significant proportion, 62.3%, had residual nodules post-surgery, and 26.6% demonstrated progression. Secondary interventions were performed on residual lesions in 32.8% of cases. The study also found a small percentage of patients (7%) developed new lesions during follow-up, with about half requiring further intervention.<br /><br />**Surgical Outcomes:** Lobectomy was the most common surgical procedure performed as both primary (67.6%) and secondary operations (8.5%). <br /><br />**Prognostic Factors:** Multivariable analyses identified smoking status and the emergence of new lesions as significant factors impacting prognosis. Notably, the invasive characteristics of the dominant tumor were highlighted as the most crucial prognostic determinant. In contrast, residual non-dominant nodules were found not to significantly affect survival. <br /><br />**Conclusion:** The research emphasizes the prognosis post-surgical treatment for multifocal GGNs is heavily influenced by the invasiveness of the dominant tumor. Although the presence of residual nodules did not majorly affect survival, a significant subset of patients required additional interventions over time for residual or new nodules.

Asset Subtitle

In Kyu Park

Meta Tag

Speaker In Kyu Park

Topic Early-Stage Non-small Cell Lung Cancer

Keywords

lung cancer

multifocal ground-glass nodules

surgical treatment

prognosis

radiologic consolidation-tumor ratio

overall survival

disease-free survival

lobectomy

prognostic factors

smoking status