2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.07A.16 The Prognostic Disparities Between the T3 Descriptors in Surgically Resected Primary Lung Cancer

Pdf Summary

The study, conducted by Ayumi Suzuki at the Cancer Institute Hospital of JFCR in Japan, investigates the prognostic disparities among different T3 descriptors in surgically resected primary lung cancer. Utilizing data from 2488 cases between 2018 and 2020, the study categorizes patients according to the eighth TNM classification: Group S (tumor size over 5 cm), Group I (chest wall invasion or parietal pleura involvement, PL3), and Group PM (pulmonary metastasis within the same lobe).<br /><br />Key findings reveal significant prognostic differences between these groups. For overall survival (OS), the five-year survival rates varied: 62.2% for size, 73.3% for invasion, and 81.3% for PM cases. Recurrence-free survival (RFS) rates were 58.2% for size and invasion, but notably higher at 74.5% for PM cases. The study identifies that patient characteristics significantly vary among the groups, with PM cases showing a higher prevalence of female patients, lighter smokers, and carriers of the EGFR mutation. <br /><br />Cox regression analysis further suggests that the type of pT3 descriptor is an influential prognostic factor for OS in T3N0M0 lung cancers, with the presence of EGFR mutation negatively affecting RFS specifically in PM cases. These findings underscore the need for more comprehensive data, including PD-L1 status and other mutation analyses, to refine therapeutic approaches and TNM staging in future studies.<br /><br />The study emphasizes the substantial variation in patient characteristics and survival outcomes among different T3 descriptors, suggesting that distinct molecular profiles, including EGFR mutation status, may play a critical role in the prognosis and management of lung cancer patients. Further research and a more nuanced collection of treatment data are recommended to enhance the understanding of these disparities in lung cancer management.

Asset Subtitle

Ayumi Suzuki

Meta Tag

Speaker Ayumi Suzuki

Topic Early-Stage Non-small Cell Lung Cancer

Keywords

lung cancer

prognostic disparities

T3 descriptors

surgical resection

TNM classification

EGFR mutation

survival rates

Cox regression analysis

patient characteristics

molecular profiles