2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.07B.05 Comparison of Image-Guided Thermal Ablation or Stereotactic Body Radiation Therapy for Primary Non-Small Cell Lung Cancer

EP.07B.05 Comparison of Image-Guided Thermal Ablation or Stereotactic Body Radiation Therapy for Primary Non-Small Cell Lung Cancer

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This study compares the efficacy and safety of image-guided thermal ablation (IGTA) and stereotactic body radiation therapy (SBRT) for treating primary non-small cell lung cancer (NSCLC). Both IGTA and SBRT are increasingly used, but there is limited evidence on their respective efficacy, complicating treatment decisions. Conducted at a tertiary medical center, this retrospective cohort study spanned from January 2011 to December 2016 for IGTA and January 2009 to December 2021 for SBRT. It included 162 tumors, with 73 treated by IGTA and 89 by SBRT.<br /><br />The study focused on treatment site progression and treatment-related adverse events (TRAEs), assessed via clinical and radiographic reports. After 12 months, SBRT showed a significant advantage with no instances of treatment site progression compared to 15.1% for IGTA. In terms of safety, 19.2% of IGTA patients experienced grade 3 TRAEs, significantly higher than the 3.4% in the SBRT group. Acute complications like pneumothorax, pleural effusion, and respiratory failure leading to death were more common in IGTA-treated patients.<br /><br />Notably, SBRT patients experienced fewer adverse effects overall. This study presents valuable insights from over 13 years of IGTA and SBRT use in NSCLC treatment, highlighting significant differences in outcomes and side effects. These findings can guide future research and clinical decisions, emphasizing SBRT's advantages in safety and efficacy over IGTA, thereby informing patient-specific treatment plans.

Asset Subtitle

John Nikitas

Meta Tag

Speaker John Nikitas

Topic Early-Stage Non-small Cell Lung Cancer

Keywords

NSCLC

image-guided thermal ablation

stereotactic body radiation therapy

treatment efficacy

treatment safety

treatment-related adverse events

tumor progression

acute complications

clinical decisions

patient-specific treatment