2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.07B.08 The Treatment Outcome of SBRT and Sublobar Resection for Vulnerable Elderly Patients with Stage IA Non-Small Cell Lung Cancer

EP.07B.08 The Treatment Outcome of SBRT and Sublobar Resection for Vulnerable Elderly Patients with Stage IA Non-Small Cell Lung Cancer

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The study investigated treatment outcomes between stereotactic body radiotherapy (SBRT) and sublobar resection for elderly patients with stage IA non-small cell lung cancer (NSCLC), focusing on those considered vulnerable due to age and health status. Specifically, it targeted patients aged 75 and older with solid-predominant tumors of 3 cm or smaller, as identified by thin-slice CT scans.<br /><br />Methods included propensity score matching to adjust for potential biases, examining factors like age, sex, smoking status, and tumor characteristics. The study entailed a data review from 2010 to 2017 involving 134 patients, of whom 86 underwent SBRT and 33 underwent sublobar resection. The follow-up schedule varied between the groups, with SBRT patients observed more frequently in the initial months post-treatment.<br /><br />Key findings showed no significant difference in overall survival and recurrence-free survival after matching between the SBRT and sublobar resection groups. The 3-year survival rates were similar: 69.4% for SBRT versus 66.7% for surgery. The recurrence rates also appeared comparable, with 21.5% for SBRT and 20.8% for surgical resection over three years. Complication rates varied, with SBRT showing fewer Grade 2 and Grade 3 complications compared to surgery. No severe toxicities (Grade 4 or higher) were reported in either group.<br /><br />The study's retrospective nature, single-institution focus, and small sample size were noted as limitations, along with the inclusion of undiagnosed patients in the SBRT group whose malignancy was monitored through growth over time.<br /><br />The conclusion suggests that SBRT offers comparable survival outcomes and may serve as a viable treatment option for elderly patients unable to undergo surgical intervention, emphasizing the need for further randomized controlled trials to confirm these findings.

Asset Subtitle

Momoko Asami

Meta Tag

Speaker Momoko Asami

Topic Early-Stage Non-small Cell Lung Cancer

Keywords

SBRT

sublobar resection

elderly patients

stage IA NSCLC

treatment outcomes

propensity score matching

survival rates

recurrence rates

complication rates

randomized controlled trials