2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.07D.01 Regional Longitudinal Evaluation of Treatment Patterns in Early-Stage Non-Small Cell Lung Cancer (ELEVATE)

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The study titled "ELEVATE" presented an observational analysis focusing on early-stage non-small cell lung cancer (NSCLC) treatment patterns and decision-making factors within the Asia-Pacific region. Conducted across Australia, Hong Kong, Singapore, South Korea, Taiwan, and Vietnam, the research recruited 212 lung cancer specialists with significant experience in managing early-stage NSCLC (Stages I-IIIB).<br /><br />The study aimed to understand the treatment choices and the factors influencing these decisions across different territories in the region. Participants primarily practiced in public, government, or university hospitals, managing a median of 30 early-stage NSCLC patients annually either independently or through co-management.<br /><br />Key findings indicated a prevalent use of surgery followed by adjuvant chemotherapy as the primary treatment for patients in the less advanced disease stages (Groups A and B) whether or not they had oncogenic mutations. For more advanced cases (Group C), definitive chemoradiation was preferred. The study also found variations in the choice of targeted therapy and immunotherapy depending on the presence of oncogenic mutations, reflecting differences in drug approvals and healthcare system policies across regions.<br /><br />The choice of systemic therapies was notably influenced by factors such as tumor size, patient performance status according to the Eastern Cooperative Oncology Group (ECOG), and nodal involvement. The research underscored the adherence to clinical guidelines for early-stage NSCLC treatment, while also highlighting some geographical variations in practice patterns.<br /><br />Overall, this study provides valuable insights into real-world treatment practices for early-stage NSCLC in the Asia-Pacific, intending to support evidence-based clinical decision-making that aligns closely with established guidelines and trial evidence. The research was supported by MSD International and conducted with assistance from IQVIA.

Asset Subtitle

Myung-Ju Ahn

Meta Tag

Speaker Myung-Ju Ahn

Topic Early-Stage Non-small Cell Lung Cancer

Keywords

ELEVATE study

NSCLC treatment

Asia-Pacific

lung cancer specialists

oncogenic mutations

adjuvant chemotherapy

definitive chemoradiation

targeted therapy

ECOG performance status

clinical guidelines