2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.07D.10 Deciphering Destiny: Is Curation of NSCLC Limited to Stage IA?

Pdf Summary

The study "Deciphering Destiny: Is Curation of NSCLC Limited to Stage IA?" investigates whether curative treatment for non-small cell lung cancer (NSCLC) leads to a normal life expectancy, with a focus on whether this is primarily achievable at stage IA. Conducted by the University Medical Center Essen and other collaborators, this study addresses the gender-specific long-term survival outcomes following anatomical resection for NSCLC.<br /><br />**Introduction and Methods:**<br />The study analyzes adult male and female patients from a single institution over a 12-year period who received NSCLC resection. Patients with stage IIIA, those who underwent neoadjuvant therapy, or had positive resection margins were excluded. Survival rates, including overall survival (OS) and disease-free survival (DFS), were calculated, focusing on the impact of gender. <br /><br />**Results:**<br />- **Patient Demographics:** Out of 4,052 patients assessed, the average age was around 66 years, with a slightly higher number of male participants. The histology showed a distribution of adenocarcinoma and squamous cell carcinoma.<br />  <br />- **Survival Analysis:** There is a significant discrepancy in survival rates favoring female patients, with females having an approximately 37-month survival advantage over their male counterparts when free from recurrence at stage IA. This aligns with the higher life expectancy of women in general populations.<br /><br />- **Hazard Ratios:** Analysis showed male patients have a hazard ratio of 2.39, indicating a higher risk of negative outcomes compared to females.<br /><br />**Discussion and Conclusion:**<br />The study suggests male patients have poorer long-term survival post-resection of NSCLC due to earlier recurrence. It posits that NSCLC may only be truly curable at stage IA, particularly given the gender disparities in survival. Disease-free survival for recurrence-free females closely matches the general life expectancy advantage observed between genders. The findings underscore the importance of early detection and treatment in curb NSCLC.

Asset Subtitle

Fabian Doerr

Meta Tag

Speaker Fabian Doerr

Topic Early-Stage Non-small Cell Lung Cancer

Keywords

NSCLC

Stage IA

curative treatment

gender-specific survival

anatomical resection

survival rates

hazard ratios

early detection

University Medical Center Essen

disease-free survival