2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.07G.01 Computed Tomography Features of Pathological Stage IA Lung Adenocarcinoma Showing Spread Through Air Spaces.

EP.07G.01 Computed Tomography Features of Pathological Stage IA Lung Adenocarcinoma Showing Spread Through Air Spaces.

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The study explores computed tomography (CT) features associated with spread through air spaces (STAS) in pathological stage IA lung adenocarcinoma. STAS, observed in non-small cell lung cancer (NSCLC), is linked to poorer prognosis post-resection. Despite limited information connecting classical CT features to STAS, this study evaluates characteristics such as vascular convergence, air bronchogram, cavity, spiculation, pleural indentation, and lobulation.<br /><br />The research compares CT features in patients with and without STAS, analyzing factors like age, sex, smoking history, body mass index, CEA levels, clinical stage, total tumor size, solid size, and ground-glass opacity (GGO) components. Findings indicate significant associations between STAS presence and the absence of an air bronchogram, but a notable presence of vascular convergence and cavity. GGO components were less common in cases with STAS.<br /><br />Recurrence-free and overall survival rates decreased in patients with STAS, highlighting poorer prognosis. Univariate and multivariate logistic regression models analyzed the probability of STAS presence, linking significant features such as vascular convergence and cavity more prominently in multivariate analyses.<br /><br />The study's limitations include its retrospective nature, single-institution focus, small sample size, and variability among raters in detecting CT features, which affects generalizability. Moreover, specific adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) cases were excluded.<br /><br />In conclusion, specific CT features like vascular convergence, air bronchogram, and cavity could characterize STAS in stage IA lung adenocarcinoma, suggesting potential for better preoperative predictions. However, further prospective research is necessary for validation and to enhance the understanding of CT predictors for STAS, aiming to improve prognostic assessments and treatment planning for lung adenocarcinoma patients.

Asset Subtitle

Tomohito Saito

Meta Tag

Speaker Tomohito Saito

Topic Early-Stage Non-small Cell Lung Cancer

Keywords

computed tomography

spread through air spaces

lung adenocarcinoma

non-small cell lung cancer

vascular convergence

air bronchogram

cavity

ground-glass opacity

prognosis

preoperative predictions