2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.07G.04 Clinical Implications of Spread Through Air Spread as Prognostic and Predictive Factors for Patients with Stage IA-B Non-Small Cell Lung Cancer

EP.07G.04 Clinical Implications of Spread Through Air Spread as Prognostic and Predictive Factors for Patients with Stage IA-B Non-Small Cell Lung Cancer

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The study examines the prognostic implications of Spread Through Air Spaces (STAS) in patients with stage IA-B Non-Small Cell Lung Cancer (NSCLC). STAS is recognized in the new 2021 WHO Classification of Lung Tumors as a histological characteristic associated with poor prognosis in early-stage lung adenocarcinoma. This research aimed to explore how STAS correlates with survival outcomes in these patients. Conducted in a retrospective cohort design, the study analyzed data from patients who underwent resection for stage IA/B NSCLC at Phramongkutklao Hospital between January 2013 and December 2021. Information on demographics, comorbidities, and pathological findings were collected, focusing on disease-free survival (DFS) outcomes in patients categorized by STAS status.<br /><br />The 5-year DFS rate for STAS-negative patients was 69.2%, while it was 49.8% for those testing positive for STAS. However, the difference was not statistically significant (p-value 0.23). Multivariate analysis revealed that factors like tumor differentiation, the extent of lymph node involvement, and regular follow-up with imaging stood out as independent prognostic factors influencing DFS.<br /><br />Despite the lack of statistical significance between the STAS-positive and STAS-negative groups in terms of DFS, the presence of STAS has potential implications for clinical decision-making in early-stage NSCLC. It suggests that STAS status could inform decisions on patient management and treatment strategies given its potential impact on survival. Therefore, incorporating STAS status in assessments may enhance the prognostic evaluation of early-stage NSCLC patients. The study underscores the potential predictive value of STAS in informing treatment and monitoring strategies for better clinical outcomes.

Asset Subtitle

Alan Patiluntakankul

Meta Tag

Speaker Alan Patiluntakankul

Topic Early-Stage Non-small Cell Lung Cancer

Keywords

STAS

Non-Small Cell Lung Cancer

NSCLC

prognostic implications

early-stage lung adenocarcinoma

disease-free survival

retrospective cohort study

Phramongkutklao Hospital

tumor differentiation

prognostic evaluation