2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.07G.07 Risk and Outcomes of Secondary Malignancy Among Non-Small Cell Lung Cancer Survivors Following Definitive Treatment

EP.07G.07 Risk and Outcomes of Secondary Malignancy Among Non-Small Cell Lung Cancer Survivors Following Definitive Treatment

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Non-small cell lung cancer (NSCLC) outcomes have improved, resulting in more long-term survivors. However, these survivors remain at significant risk for both disease recurrence and non-lung secondary malignancies (NLSM). This study, conducted at Memorial Sloan Kettering Cancer Center, aimed to characterize NLSMs and subsequent outcomes in NSCLC survivors.<br /><br />The study assessed 300 NSCLC survivors, focusing on those staged I-III who had completed definitive treatment and remained disease-free for at least 12 months. Over a median follow-up of 6 years, 17% experienced cancer recurrence. Additionally, 23% developed secondary malignancies, with a median onset at 58 months post-treatment. Of these, 10% developed NLSMs, typically diagnosed over 3 years after initial treatment.<br /><br />A significant finding was that 17% of patients with NLSM had metastatic disease, with a median overall survival (OS) of 6 months for these cases. For the broader group of patients with NLSMs, the median OS was 26 months, and median progression-free survival was 19 months.<br /><br />The risk of developing an NLSM increased over time, reaching 10% at 7 years post-treatment. The study suggests that many NLSMs are not detected by routine chest CT scans, emphasizing the need for comprehensive long-term surveillance strategies beyond standard practices.<br /><br />These insights underline the importance of continued vigilance for secondary malignancies in NSCLC survivors, proposing ongoing and possibly more comprehensive follow-up care to improve detection and management of NLSMs. The results highlight the necessity for alternative surveillance approaches to better address the risks faced by this patient population.

Asset Subtitle

Orly Yariv

Meta Tag

Speaker Orly Yariv

Topic Early-Stage Non-small Cell Lung Cancer

Keywords

NSCLC

non-small cell lung cancer

long-term survivors

disease recurrence

secondary malignancies

NLSM

Memorial Sloan Kettering

surveillance strategies

follow-up care

cancer recurrence