2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.08B.02 The Impact of C-Met Expression on the Immune Microenvironment and Survival in Locally Advanced Non-Small Cell Lung Cancer

EP.08B.02 The Impact of C-Met Expression on the Immune Microenvironment and Survival in Locally Advanced Non-Small Cell Lung Cancer

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The study investigates the impact of c-MET expression on the immune microenvironment and survival in patients with locally advanced non-small cell lung cancer (NSCLC). c-MET, a protein often overexpressed or mutated in various cancers, is linked to poor prognosis and affects the tumor immune microenvironment (TIME), potentially influencing the efficacy of immune checkpoint inhibitors and other therapies.<br /><br />The research focuses on 60 NSCLC patients from Shanghai Pulmonary Hospital who underwent radiotherapy followed by immunotherapy. These patients were monitored from September 2019 to November 2023. Key factors for inclusion involved advanced cancer stages unsuitable for surgery and specific treatment regimens, while exclusion criteria included immunodeficiency and active autoimmune conditions.<br /><br />Findings reveal that high c-MET expression is significantly associated with reduced progression-free survival (PFS) and overall survival (OS), with median PFS and OS recorded at 24 and 34 months, respectively. A significant association was also found between reduced macrophage (CD68) infiltration and improved OS. Notably, patients with PD-L1-positive profiles showed longer survival spans, though this was not statistically significant.<br /><br />Correlation analysis highlighted a positive connection between c-MET intensity and CD68 infiltration, as well as PD-L1 expression, suggesting a link between the MET signaling pathway and macrophage infiltration. This relationship aligns with previous studies and could indicate potential applications for immune checkpoint inhibitors (ICIs) in patients with altered MET expression.<br /><br />The study identifies c-MET expression and macrophage infiltration as potential predictors of survival in NSCLC, calling for further research into their complex interaction mechanisms to improve targeted therapeutic strategies.

Asset Subtitle

Yaping Xu

Meta Tag

Speaker Yaping Xu

Topic Local-Regional Non-small Cell Lung Cancer

Keywords

c-MET expression

immune microenvironment

non-small cell lung cancer

NSCLC

tumor immune microenvironment

immune checkpoint inhibitors

macrophage infiltration

PD-L1 expression

progression-free survival

overall survival