2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.08D.13 Macrophage Polarization States Predicting the Efficacy of Neoadjuvantchemoimmunotherapyin Resectable or Potentially Resectable NSCLC

EP.08D.13 Macrophage Polarization States Predicting the Efficacy of Neoadjuvantchemoimmunotherapyin Resectable or Potentially Resectable NSCLC

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This study explores the predictive role of macrophage polarization states in assessing the efficacy of neoadjuvant chemoimmunotherapy in patients with resectable or potentially resectable non-small cell lung cancer (NSCLC). Senior authors from various medical and research institutions in China have collaborated on this research. The study categorizes patients into Major Pathological Response (MPR) and non-MPR groups based on the extent of tumor necrosis observed in resected tissue samples (MPR being defined as at least 90% tumor necrosis).<br /><br />Using multiple immunofluorescence (mIF) assays, the study detects macrophage polarization states through biomarkers like CD68, CD86, IRF5 for M1 macrophages, and CD163, CD206 for M2 macrophages. M1 macrophages generally have anti-tumoral activity and release pro-inflammatory cytokines, while M2 macrophages are associated with pro-tumoral activities and produce immune-suppressive cytokines.<br /><br />The study examined a total of 14 patient samples post-chemoimmunotherapy and surgery, equally divided between MPR and non-MPR groups for mIF analysis. Findings revealed a higher density of M2-polarized macrophages compared to M1 in both groups, indicating a predominance of immune-suppressive environments irrespective of response classification. In the MPR group, the median densities of M2 and M1 macrophages were lower compared to the non-MPR group, but with overlapping ranges. The median difference in density values between M1 and M2 macrophages was notably less in the MPR group compared to the non-MPR group, suggesting a potential correlation between macrophage polarization and therapeutic response.<br /><br />Overall, the study suggests that macrophage polarization states could inform predictive models for assessing therapeutic efficacy in NSCLC, though further comprehensive studies are needed to validate these findings.

Asset Subtitle

Ziyi Xu

Meta Tag

Speaker Ziyi Xu

Topic Local-Regional Non-small Cell Lung Cancer

Keywords

macrophage polarization

chemoimmunotherapy

non-small cell lung cancer

NSCLC

Major Pathological Response

tumor necrosis

M1 macrophages

M2 macrophages

immune-suppressive environment

therapeutic efficacy