2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.08D.15 Radical Surgery after Induction Therapy for Initially Unresectable Stage III Non-small Cell Lung Cancer

EP.08D.15 Radical Surgery after Induction Therapy for Initially Unresectable Stage III Non-small Cell Lung Cancer

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The document discusses a study evaluating the outcomes of radical surgery following induction therapy in patients with initially unresectable stage III non-small cell lung cancer (NSCLC). Conducted from August 2021 to January 2024, the study included 30 patients treated primarily with immunochemotherapy, while smaller groups received chemotherapy or targeted therapy. Following these treatments, participants underwent surgery to assess the feasibility and safety of the approach. <br /><br />Key results included a high R0 resection rate of 93.3%, indicating successful removal of visible tumors in the majority of cases. Pathological outcomes showed that a major pathological response (MPR) was achieved in 66.7% and complete pathological remission (pCR) in 30% of the patients. The study highlighted acceptable levels of surgical-related morbidity, with 33.3% of patients experiencing postoperative complications, but no in-hospital mortality. One patient died within 30 to 90 days post-surgery. Nonetheless, the one-year disease-free survival (DFS) rate was 87.5%, while the overall survival (OS) rate stood at 96.7%.<br /><br />Other documented outcomes included lymph nodes count, operation time, blood loss, and postoperative recovery statistics, such as extubation time and duration of hospital stays. The study emphasized the more favorable surgical outcomes following induction therapy for initially unresectable patients but highlighted the importance of careful patient selection and surgical indications. The authors concluded that radical surgery, post-induction therapy, is a viable option for this subset of NSCLC patients with favorable survival outcomes while maintaining a reasonable safety profile. The study was conducted at the Department of Thoracic Surgery, Ruijin Hospital, Shanghai, without reported conflicts of interest.

Asset Subtitle

Yan Yan

Meta Tag

Speaker Yan Yan

Topic Local-Regional Non-small Cell Lung Cancer

Keywords

NSCLC

radical surgery

induction therapy

immunochemotherapy

pathological response

surgical morbidity

disease-free survival

overall survival

Ruijin Hospital

thoracic surgery