2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.08E.05 The Presence of NSCLC Results in Diminished Ventilation in the Affected Lung

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The study conducted by the Department of Thoracic Oncology and Surgery at Guangzhou Medical University examined the impact of non-small cell lung cancer (NSCLC) on lung function. A cohort of 365 patients with a single confirmed NSCLC lesion was analyzed to explore how these tumors affect lung ventilation. <br /><br />Patients were predominantly male (67.7%), with ages ranging from 9 to 88 years. Tumors were located almost equally in the left (47.9%) and right lungs (52.1%). The majority of tumors were adenocarcinomas (66.6%), followed by squamous cell carcinoma (33.4%).<br /><br />Through the use of ventilation-perfusion scintigraphy (VPS), it was found that NSCLC presence significantly diminished ventilation in the affected lung compared to the opposite, tumor-free lung. Chi-square analyses demonstrated higher ventilation in non-tumor-affected lungs regardless of histological type (adenocarcinoma or squamous cell carcinoma). These changes were statistically significant for squamous cell carcinoma patients but not for adenocarcinoma patients.<br /><br />Survival analysis revealed that impaired ventilation in the lung affected by the tumor was linked to worsened patient prognosis. While the precise location of the tumor within the lung was not an independent predictor of survival, patients exhibiting greater ventilation impairment tended to fare worse over a five-year period.<br /><br />The study concludes that the presence of NSCLC negatively impacts lung ventilation, which may contribute to poorer survival outcomes. The findings underscore the importance of assessing lung ventilation in NSCLC patients for a potentially improved management approach and better understanding of their prognosis.

Asset Subtitle

Kai Yu

Meta Tag

Speaker Kai Yu

Topic Local-Regional Non-small Cell Lung Cancer

Keywords

NSCLC

lung function

ventilation

adenocarcinoma

squamous cell carcinoma

ventilation-perfusion scintigraphy

prognosis

survival analysis

Guangzhou Medical University

lung cancer