2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.08F.01 Predicting Radiation Pneumonitis with Baseline Pulmonary Function Tests in Patients with Locally Advanced Non-Small Cell Lung Cancer (NSCLC)

EP.08F.01 Predicting Radiation Pneumonitis with Baseline Pulmonary Function Tests in Patients with Locally Advanced Non-Small Cell Lung Cancer (NSCLC)

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This study investigates the predictive value of baseline pulmonary function tests (PFTs) for radiation pneumonitis (RP) in patients with locally advanced non-small cell lung cancer (NSCLC) undergoing chemoradiation therapy (CRT). RP is a significant complication affecting therapeutic decisions, especially concerning consolidation immunotherapy.<br /><br />The study included 81 patients with unresectable stage II-III NSCLC treated at a tertiary hospital without immunotherapy between 2010 and 2021. All patients had undergone PFTs within one year before treatment, and baseline lung conditions such as COPD/emphysema were evaluated using CT scans.<br /><br />The incidence of RP was evaluated using CT scoring based on the density and extent of lung opacities, with RP defined by a radiographic score of 6 or clinical documentation. Key findings include:<br /><br />- RP was present in 44.4% of patients.<br />- A higher diffusing capacity of the lungs for carbon monoxide (DLCO) and a lower residual volume to total lung capacity (RV/TLC) ratio were associated with increased risk of RP.<br />- DLCO showed a positive correlation with RP, while RV/TLC demonstrated a negative correlation.<br />- Radiographic evidence of baseline COPD/emphysema correlated with a decreased risk of RP.<br />- No correlation was found between the radiation dose and any PFT or radiographic parameter.<br /><br />The study suggests that evaluating functional lung volumes through PFTs and radiographic assessments can aid in predicting RP risk in NSCLC patients undergoing CRT. Identifying patients at higher risk of RP could improve management strategies and tailor treatments to minimize adverse effects. This research highlights the critical role of comprehensive baseline assessments in effectively predicting and mitigating radiation-induced complications in lung cancer therapy.

Asset Subtitle

Sooyun Tavolacci

Meta Tag

Speaker Sooyun Tavolacci

Topic Local-Regional Non-small Cell Lung Cancer

Keywords

pulmonary function tests

radiation pneumonitis

non-small cell lung cancer

chemoradiation therapy

baseline assessment

DLCO

RV/TLC ratio

COPD

immunotherapy

lung cancer therapy