2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.08F.20 Stage IIIA Non-Small Cell Lung Cancer (NSCLC): Outcomes by Treatment Strategy

Pdf Summary

This study examines treatment outcomes for Stage IIIA Non-Small Cell Lung Cancer (NSCLC) based on different treatment strategies, conducted by researchers from UCSF East Bay and Kaiser Permanente. Stage IIIA NSCLC treatment can involve complex decision-making regarding the use of surgical versus non-surgical strategies, with resectability being a critical factor affecting patient outcomes.<br /><br />A retrospective analysis was conducted using data from January 1, 2010, to June 30, 2021, encompassing 595 patients. The study compared outcomes between two cohorts: those receiving non-surgical treatment, which includes chemoradiotherapy and immunotherapy, and those undergoing surgery combined with neoadjuvant or adjuvant chemotherapy, radiation, or immunotherapy.<br /><br />Key findings indicated that patients receiving surgical treatment had a significantly improved 5-year overall survival rate of 52.6%, compared to 30.8% for patients undergoing non-surgical treatment. The cohorts were similar in terms of demographic and clinical characteristics, including age, BMI, CCS, race, and date of diagnosis.<br /><br />The results align with previous clinical trials conducted in 2009 and highlight the advancements in treatment outcomes following the adoption of immunotherapy. The study emphasizes the benefit of a multidisciplinary approach to treatment, advocating for the involvement of thoracic surgeons and a team-based strategy to optimize patient outcomes.<br /><br />The survival probability over time suggests better outcomes for those in the surgical group (arm 1), as evidenced by the log-rank test showing a significant difference (p < 0.0001) between the survival curves of surgical and non-surgical treatments. This reinforces the therapeutic advantage of surgical intervention in Stage IIIA NSCLC when feasible.

Asset Subtitle

William Carroway

Meta Tag

Speaker William Carroway

Topic Local-Regional Non-small Cell Lung Cancer

Keywords

Stage IIIA NSCLC

treatment outcomes

surgical strategies

non-surgical treatment

immunotherapy

5-year survival rate

multidisciplinary approach

thoracic surgeons

retrospective analysis

survival probability