2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.11A.20 Incidence and Outcomes of Adrenal Oligoprogression in Metastatic Lung Cancer During Immunotherapy

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The study titled "Incidence and Outcomes of Adrenal Oligoprogression in Metastatic Lung Cancer During Immunotherapy" investigates the occurrence and implications of adrenal oligoprogression in patients with metastatic lung cancer treated with immunotherapy. Conducted by Beatriz Viesser Miyamura and collaborators at Hospital Israelita Albert Einstein and Hospital Municipal Vila Santa Catarina in Brazil, this retrospective analysis draws from patient records between 2017 and 2022.<br /><br />Key findings indicate that among 159 patients treated with anti-PD-(L)1 immunotherapy, either alone or in combination with chemotherapy, 37 had adrenal metastasis during or before treatment. Notably, the incidence of adrenal oligoprogression — where disease progression is isolated to the adrenal glands without affecting other sites — was 24.3%.<br /><br />While the study observed that overall survival (OS) was numerically longer in patients experiencing adrenal oligoprogression compared to those with broader disease progression, the difference was not statistically significant. This lack of statistical significance could be attributed to the relatively small sample size, with a p-value of 0.057 failing to meet typical thresholds for statistical significance.<br /><br />The research concludes that adrenal oligoprogression is a significant phenomenon in metastatic lung cancer patients undergoing immunotherapy. It suggests the adrenal gland might act as a sanctuary for metastases, potentially reducing the efficacy of systemic cancer treatments like immunotherapy. These findings underscore the need for further research to understand the mechanisms of disease resistance in the adrenal gland during immunotherapy, which could inform future therapeutic strategies.<br /><br />The study highlights the complex response patterns in metastatic sites like the adrenal glands and emphasizes the necessity for targeted research to validate these initial findings and explore potential interventions.

Asset Subtitle

Beatriz Miyamura

Meta Tag

Speaker Beatriz Miyamura

Topic Metastatic Non-small Cell Lung Cancer – Immunotherapy

Keywords

adrenal oligoprogression

metastatic lung cancer

immunotherapy

adrenal metastasis

anti-PD-(L)1

overall survival

disease resistance

retrospective analysis

Brazil

therapeutic strategies