2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.11B.05 The Differential Effect of Radiation, IL39, and the Combination on Expression of HLA Molecules

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The study titled "The Differential Effect of Radiation, IL39, and the Combination on Expression of HLA Molecules" explores innovative treatment strategies for adenocarcinoma, a lung cancer type notoriously resistant to conventional therapies with a mean survival rate under five years. With the growing interest in immunotherapies, the study specifically analyzes the novel signaling molecule IL39, recognized for its anti-cancer effects through the upregulation of MHC molecules and downregulation of pro-inflammatory markers.<br /><br />Using RT-PCR and immunohistochemistry, the researchers tested the effects of standalone radiation, IL39, and their combination on the adenocarcinoma cell line A549. The focus was on the expression of anti-cancer molecules HLA-DQA, HLA-DQB, HLA-DPA, and the pro-inflammatory molecule CD74. Results showed that while radiation alone upregulated HLA-DQA, IL39 alone led to the upregulation of HLA-DQA, HLA-DQB, and HLA-DPA. The combination therapy enhanced HLA-DQA expression and simultaneously downregulated CD74, a finding suggesting dual benefits in cancer management.<br /><br />This study is significant as it is the first to examine IL39’s influence on HLA molecule regulation and the synergistic potential of combining IL39 with radiation, pointing toward promising implications for transitioning cancer care to more effective, targeted immunotherapy approaches. The downregulation of pro-cancer markers in addition to upregulating anti-cancer proteins highlights the potential of IL39, alone or in tandem with radiation, to offer enhanced therapeutic effects against cancer. The research underscores the importance of continuing this line of study to advance cancer treatment strategies and improve outcomes for patients with cancers that are currently hard to treat.

Asset Subtitle

Erin Kaser

Meta Tag

Speaker Erin Kaser

Topic Metastatic Non-small Cell Lung Cancer – Immunotherapy

Keywords

adenocarcinoma

immunotherapy

IL39

HLA molecules

radiation therapy

A549 cell line

MHC upregulation

CD74 downregulation

cancer treatment

targeted therapy