2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.13B.04 The Value of Radiotherapy Based on the Failure of Extensive-Stage Small Cell Lung Cancerin the Era of Immunotherapy

EP.13B.04 The Value of Radiotherapy Based on the Failure of Extensive-Stage Small Cell Lung Cancerin the Era of Immunotherapy

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This study by Qin Zhang from Shanghai Chest Hospital investigates the role of radiotherapy (RT) in conjunction with immune checkpoint inhibitors (ICIs) for patients with extensive-stage small cell lung cancer (ES-SCLC). While ICIs have enhanced overall survival for these patients, the specific function of RT in this therapeutic era remains unclear. The study employed a retrospective analysis of patient data, focusing on the first patterns of disease progression and evaluating the potential benefits of RT.<br /><br />The study found that disease progression occurred in 68% of the 86 patients analyzed. These patients were divided into two groups based on when they received RT: 14 in the pre-progression RT group and 72 in the non-pre-progression RT group. Results indicated that median overall survival (mOS) was longer for the RT group, at 21.4 months, compared to 11.9 months for the non-RT group. Additionally, median progression-free survival (mPFS) was greater for the pre-progression RT group (8.6 months) compared to the post-progression group (6.7 months), demonstrating a significant improvement in PFS when RT was administered before tumor progression.<br /><br />The primary failure pattern identified was distant failure. Despite the observed advantage in terms of survival and disease progression timing, the study concludes that further clinical trials are necessary to confirm the optimal timing and efficacy of RT for ES-SCLC patients in the context of immunotherapy. Overall, the research suggests that RT administered prior to tumor progression may offer meaningful survival benefits in the management of ES-SCLC.

Asset Subtitle

Qin Zhang

Meta Tag

Speaker Qin Zhang

Topic Small Cell Lung Cancer and Neuroendocrine Tumors

Keywords

radiotherapy

immune checkpoint inhibitors

extensive-stage small cell lung cancer

Shanghai Chest Hospital

disease progression

overall survival

progression-free survival

retrospective analysis

distant failure

clinical trials