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2024 World Conference on Lung Cancer (WCLC) - ePos ...
EP.13B.08 Enhanced Efficacy of Anlotinib in Small ...
EP.13B.08 Enhanced Efficacy of Anlotinib in Small Cell Lung Cancer after Immune Checkpoint Inhibitor Exposure
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This study evaluates the efficacy of anlotinib, an anti-angiogenic drug, as a third-line treatment for patients with extensive-stage small cell lung cancer (ES-SCLC) who were previously exposed to immune checkpoint inhibitors (ICIs). The retrospective analysis involved 59 patients: 39 who had prior ICI exposure and 20 who had not.<br /><br />The primary endpoints of the study were progression-free survival (PFS) and overall survival (OS), with secondary endpoints focused on safety and adverse events. The study found that the PFS for the ICI-exposed group reached 11 months, significantly longer than 4 months for the control group. Similarly, overall survival was 21 months for patients with prior ICI treatment, compared to 10 months for those without, suggesting a significant benefit from anlotinib post-ICI therapy.<br /><br />Adverse events (AEs) were reported with Grade 3 or higher in 15% of the treatment group and 17.9% of the control group, with proteinuria being the most common severe AE. Other documented adverse events include hypertension, fatigue, and liver dysfunction, mainly occurring at Grades 1 and 2, with a few at Grade 3 or 4.<br /><br />These findings suggest that previous exposure to ICIs may enhance the efficacy of anlotinib in patients with SCLC, potentially offering a new treatment pathway. However, further prospective studies are necessary to confirm these results and understand the mechanisms involved.<br /><br />Baseline characteristics of the study participants showed a median age of 64 years, predominantly male (94.9%). Most participants had an Eastern Cooperative Oncology Group (ECOG) performance status of 1.<br /><br />Anlotinib as a third-line therapy, particularly after ICI treatment, underscores a promising strategy in managing ES-SCLC, suggesting improved outcomes in terms of both progression and overall survival.
Asset Subtitle
Jianzhen Shan
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Speaker
Jianzhen Shan
Topic
Small Cell Lung Cancer and Neuroendocrine Tumors
Keywords
anlotinib
anti-angiogenic
third-line treatment
extensive-stage small cell lung cancer
immune checkpoint inhibitors
progression-free survival
overall survival
adverse events
retrospective analysis
ECOG performance status
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