2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.13C.06 Feasibility of Hippocampal Sparing Radiotherapy in Lung Cancer Patients Requiring Cranial Irradiation (HSWBRT-LC)

EP.13C.06 Feasibility of Hippocampal Sparing Radiotherapy in Lung Cancer Patients Requiring Cranial Irradiation (HSWBRT-LC)

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The study titled "Feasibility of Hippocampal Sparing Radiotherapy in Lung Cancer Patients Requiring Cranial Irradiation (HSWBRT-LC)" conducted by Dr. Divya Khosla and colleagues from the Post Graduate Institute of Medical Education and Research, Chandigarh, evaluated the potential of HSWBRT to mitigate neurocognitive decline in lung cancer patients undergoing whole brain radiotherapy (WBRT).<br /><br />WBRT is commonly used to treat patients with lung cancer needing cranial irradiation, but it often leads to neurocognitive side effects, compromising the quality of life. The study proposed hippocampal sparing as a method to improve outcomes by planning radiotherapy treatments to avoid the hippocampal region.<br /><br />Conducted from 2021 to 2023 and approved by the institute's ethics committee, the prospective study aimed to assess neurocognitive function and quality of life (QOL) improvements as the primary objective, with secondary objectives focusing on intracranial relapse rates and overall survival (OS).<br /><br />Results with a median follow-up of 19 months displayed no significant differences in intracranial relapse rates between HSWBRT and traditional WBRT treatments. However, HSWBRT showed promising outcomes in maintaining neurocognitive function and enhancing QOL, as well as having a better OS rate at 18 months (67.7% vs. 50% for WBRT). One-year OS was 100% for the HSWBRT group compared to 86.7% for WBRT. Furthermore, patient deaths were lower in the HSWBRT group (4/15) versus the WBRT group (7/15).<br /><br />Overall, the study suggests that HSWBRT could be a viable approach for sparing cognitive function without increasing intracranial relapse risk, potentially offering improved survival benefits for lung cancer patients.

Asset Subtitle

Divya Khosla

Meta Tag

Speaker Divya Khosla

Topic Small Cell Lung Cancer and Neuroendocrine Tumors

Keywords

Hippocampal Sparing Radiotherapy

Lung Cancer

Neurocognitive Decline

Whole Brain Radiotherapy

Quality of Life

Intracranial Relapse

Overall Survival

Prospective Study

Cranial Irradiation

Survival Benefits