2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.13D.02 Low to Intermediate Grade Lung Neuroendocrine Tumours. A Single Centre Real World Experience

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This document presents findings from a study at The Ottawa Hospital Cancer Centre on low to intermediate grade lung neuroendocrine tumors (LNETs). As rare neoplasms with varied clinical behaviors, these tumors are increasing in incidence. Common treatments for LNETs include surgical options, radiation, and systemic therapies such as somatostatin analogues (SSA), chemotherapy, everolimus, and peptide receptor radionuclide therapy (PRRT).<br /><br />The study's objective was to explore diagnostic processes, treatment approaches, and outcomes for patients with low to intermediate grade LNETs. Patients over 18, treated from June 2010 to June 2021, were included in the cohort. Data was collected from electronic medical records and analyzed using statistical software like R. Key patient characteristics included a median age of 64.5, with a higher prevalence in females. Most presented with Stage I tumors and underwent curative surgeries which indicated a favorable overall survival.<br /><br />Pathology results highlighted varying tumor stages and differentiation levels with most tumors being well-differentiated. Treatment methods varied depending on the stage at diagnosis; early-stage patients primarily received surgery or radiation. For those with advanced or unresectable diseases, systemic therapies were utilized, yet optimal treatment sequences remain uncertain.<br /><br />The study concludes that patients largely presented with local or locally advanced disease and those undergoing curative resection had better survival rates. Despite various treatment regimens for advanced disease, a standardized sequence remains undetermined, pointing to a need for further research and consensus on managing advanced LNETs. The findings underscore the clinical variability of LNETs and the challenge in developing optimal treatment pathways. Overall, these results contribute valuable real-world insights into the management of these rare tumors.

Asset Subtitle

Jacqueline Martin

Meta Tag

Speaker Jacqueline Martin

Topic Small Cell Lung Cancer and Neuroendocrine Tumors

Keywords

Ottawa Hospital Cancer Centre

lung neuroendocrine tumors

LNETs

surgical options

somatostatin analogues

peptide receptor radionuclide therapy

diagnostic processes

curative surgeries

treatment sequences

real-world insights