2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.13D.06 Factors Affecting Outcomes of Limited-Stage I, IIA (T1-T2, N0, M0) Small Cell Lung Cancer: An Analysis of the National Cancer Database.

EP.13D.06 Factors Affecting Outcomes of Limited-Stage I, IIA (T1-T2, N0, M0) Small Cell Lung Cancer: An Analysis of the National Cancer Database.

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The study conducted by Hafez M. Abdullah and his colleagues at the University of Nebraska Medical Center analyzed the outcomes of early-stage small cell lung cancer (SCLC) using data from the National Cancer Database (NCDB). It focused on patients with stage I to IIA tumors (T1-T2, N0, M0) diagnosed between 2010 and 2020. The study aimed to determine factors influencing treatment and survival.<br /><br />Key findings showed that overall survival (OS) was significantly influenced by age, gender, race, and treatment type. Older patients, particularly those over 75, exhibited poorer survival rates, as did male patients and those diagnosed between 2010-2015. Conversely, treatment between 2016-2020, female gender, and care at academic or research centers were linked to better outcomes. Surprisingly, non-Caucasian groups, such as African Americans and other racial minorities, generally had better survival compared to Native Americans.<br /><br />A critical finding was the association of surgical intervention with improved outcomes, highlighting the importance of surgery in treating early-stage SCLC. Patients advised to undergo surgery but did not receive it, and those never given the option, faced worse survival outcomes. Additionally, being uninsured correlated with poorer survival.<br /><br />The study suggests a disparity in treatment recommendations based on age, as fewer older patients were suggested surgery or radiation. This highlights a potential age-bias or risk-aversion in treatment strategies for the elderly.<br /><br />In conclusion, the analysis underscores the significant impact of demographic and treatment variables on the survival of early-stage SCLC patients. Effective management including surgery, alongside considerations for demographic disparities, could enhance patient outcomes in this cohort.

Asset Subtitle

Hafez Abdullah

Meta Tag

Speaker Hafez Abdullah

Topic Small Cell Lung Cancer and Neuroendocrine Tumors

Keywords

small cell lung cancer

early-stage SCLC

National Cancer Database

treatment outcomes

survival rates

surgical intervention

demographic disparities

age bias

treatment strategies

patient outcomes