2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.13D.09 Characteristics and Survival in Never-Smoking Small Cell Lung Cancer Cases an Analysis from the Thoracic Tumor Registry

EP.13D.09 Characteristics and Survival in Never-Smoking Small Cell Lung Cancer Cases an Analysis from the Thoracic Tumor Registry

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The study investigates the characteristics and survival of never-smokers diagnosed with Small Cell Lung Cancer (SCLC), a notably aggressive form of lung cancer. While SCLC is typically linked to tobacco use, this research sheds light on the subset of patients who have never smoked. These never-smokers account for 2.7% of lung cancer cases registered.<br /><br />Key findings include a predominance of women among these patients, comprising 69.8% of the case pool. Most patients, nearly 71%, are diagnosed with an extended form of SCLC, which typically correlates with a lower one-year survival rate compared to limited cases. Symptoms at diagnosis vary, with cough being the most common at 34.1%.<br /><br />The study utilized the Spanish Lung Cancer Group Thoracic Tumour Registry for data collection and employed descriptive and Kaplan-Meier survival analyses. Median age at diagnosis was found to be 71 years, and approximately 68.6% of patients presented at least one comorbidity at the time of diagnosis. The study further noted that 16.3% had been exposed to secondhand smoke within the past 20 years.<br /><br />In terms of survival rates, the one-year survival rate for all SCLC cases was 47.1%. However, the stage of cancer at diagnosis significantly impacts prognosis: limited SCLC had a one-year survival rate of 66%, while extended SCLC cases had a rate of 37.9%.<br /><br />This study highlights the need for further research into SCLC among never-smokers to better understand risk factors, develop effective screening protocols, and improve survival outcomes.

Asset Subtitle

Cristina Candal-Pedreira

Meta Tag

Speaker Cristina Candal-Pedreira

Topic Small Cell Lung Cancer and Neuroendocrine Tumors

Keywords

never-smokers

Small Cell Lung Cancer

SCLC

survival rates

women predominance

extended SCLC

secondhand smoke

Kaplan-Meier analysis

Spanish Lung Cancer Group

lung cancer research