2024 World Conference on Lung Cancer (WCLC) - ePosters-EP.13D.13 Exploring COVID-19's Impact on Treatment and Survival in Small Cell Lung Cancer

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The study investigates the association between COVID-19 infection and outcomes for patients with Small Cell Lung Cancer (SCLC), a cancer type known for its aggressive nature and poor prognosis. Conducted as a retrospective cohort study using the TriNetX database and US Collaborative Network, the research employs propensity score matching based on demographic and health factors to examine relative risks for mortality and treatment-related adverse outcomes from 2019 to 2023.<br /><br />Key findings reveal an unexpected result at the 1-year mark, showing a significant decrease in relative mortality risk (RR 0.73, 95% CI: [0.54, 0.98], p=0.03) for COVID-19 positive SCLC patients compared to those who were COVID-19 negative. This suggests a potential benefit of supportive therapies commonly used for both SCLC and COVID-19. However, by the 3-year mark, the reduction in mortality was not statistically significant (RR 0.87, 95% CI: [0.70, 1.08], p=0.20).<br /><br />Additionally, no significant differences were observed in treatment-related adverse outcomes, such as heart or renal failure and hemorrhage, between the two groups at both the 1-year and 3-year intervals.<br /><br />The study acknowledges the inherent limitations of retrospective reviews, including potential biases due to variations in staging data and coding practices. It recommends more research into factors like COVID-19 vaccination status and the role of telehealth in improving treatment adherence and outcomes.<br /><br />The results highlight the unexpected benefit seen in reduced mortality risks at 1-year for COVID-19 positive patients, emphasizing the importance of a multidisciplinary approach in patient care and the potential for innovative therapeutic strategies that address multiple conditions.

Asset Subtitle

Lilly Hou

Meta Tag

Speaker Lilly Hou

Topic Small Cell Lung Cancer and Neuroendocrine Tumors

Keywords

COVID-19

Small Cell Lung Cancer

SCLC

mortality risk

retrospective cohort study

propensity score matching

TriNetX database

treatment-related adverse outcomes

supportive therapies

multidisciplinary approach